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• W1977026943 abstract "The interconversion of estrone (E₁) and 17β-estradiol (E₂) is catalyzed by 17β-hydroxysteroid dehydrogenase (17β-HSD) in peripheral steroidogenic organs such as the skin. To investigate gender differences of activity and skin distribution of 17β-HSD in human skin, enzymatic activity was measured in skin homogenates and skin horizontally sliced by 10 µm thickness in vitro. Reductive 17β-HSD (E₂ formation from E₁) in female skin has a lower substrate affinity than in male skin; K_m (Michaelis-Menten constant) of female and male skin is 11.8 ± 6.5 and 2.0 ± 2.0 µ<i>M</i>, respectively. Female skin had a tendency to activate estrogen; V_max (maximum rate) for E₂ formation, 5.8 ± 4.0 pmol/min/mg protein, is 1.7 times larger than E₁ formation, 3.5 ± 1.5 pmol/min/mg protein, and, on the other hand, male skin tends to deactivate estrogen; V_max for E₁ and E₂ is 10.5 ± 6.1 and 4.2 ± 3.7 pmol/min/mg protein, respectively. The concentration of metabolite had a peak value at 80–120 µm from the skin surface. Therefore, these in vitro results suggest that the enzymatic activities of 17β-HSDs have a gender difference in estrogen formation/metabolism and are distributed around the basement layer of the epidermis irrespective of sex. 17β-HSDs distributed around the basement epidermis may be effectively supplied with circulating estrogen from the papillary plexus to maintain the estrogen level in skin. This distribution pattern having a peak surrounding 100 µm from the skin surface indicates the importance for defense from noxae (e.g. detoxication) and maintenance of the internal environment (e.g. biosynthesis of hormones). Future studies should increase sample size and confirm these results by stricter statistical analysis." @default.
• W1977026943 created "2016-06-24" @default.
• W1977026943 creator A5031933716 @default.
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• W1977026943 date "2007-01-01" @default.
• W1977026943 modified "2023-09-26" @default.
• W1977026943 title "Gender Differences of Enzymatic Activity and Distribution of 17β-Hydroxysteroid Dehydrogenase in Human Skin in vitro" @default.
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• W1977026943 doi "https://doi.org/10.1159/000101386" @default.
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