Matches in SemOpenAlex for { <https://semopenalex.org/work/W197702880> ?p ?o ?g. }
- W197702880 endingPage "336" @default.
- W197702880 startingPage "299" @default.
- W197702880 abstract "Currently used drugs that are effective treatments for schizophrenia have one single factor in common — their ability to antagonise the actions of dopamine at post-synaptic dopamine D2 receptors [1–4]. This action is at the cornerstone of the dopamine hypothesis of schizophrenia and has served as the basis of the primary screen for the discovery of structurally diverse antipsychotic compounds for almost twenty years. However, general blockade of D2 receptors in the CNS is associated with two major side effects: (i) the induction of abnormal movement syndromes [5] and (ii) the stimulation of prolactin secretion [6, 7]. Furthermore, most antipsychotic drugs are effective treatments for the positive symptoms of schizophrenia (delusions, hallucinations, thought disorders), but their efficacy against the negative symptoms associated with the disease (flattening of affect, poverty of speech, loss of volition) is less easy to demonstrate [8]. Many compounds also have autonomic and cardiovascular effects that can limit their usefulness [9]. Thus, much effort has been, and is currently being, expended in the search for ways of attenuating dopaminergic function without inducing motor, hormonal or other potentially harmful side-effects, yet retaining or improving clinical efficacy." @default.
- W197702880 created "2016-06-24" @default.
- W197702880 creator A5030640333 @default.
- W197702880 creator A5067902930 @default.
- W197702880 creator A5085278505 @default.
- W197702880 date "1992-01-01" @default.
- W197702880 modified "2023-09-24" @default.
- W197702880 title "Alternative approaches to the discovery of novel antipsychotic agents" @default.
- W197702880 cites W1561239748 @default.
- W197702880 cites W1635864650 @default.
- W197702880 cites W1780685243 @default.
- W197702880 cites W1840994181 @default.
- W197702880 cites W1964103066 @default.
- W197702880 cites W1964538374 @default.
- W197702880 cites W1965058910 @default.
- W197702880 cites W1965260950 @default.
- W197702880 cites W1966092598 @default.
- W197702880 cites W1966679583 @default.
- W197702880 cites W1967099480 @default.
- W197702880 cites W1968424035 @default.
- W197702880 cites W1969803056 @default.
- W197702880 cites W1970596190 @default.
- W197702880 cites W1971579442 @default.
- W197702880 cites W1972232167 @default.
- W197702880 cites W1972579416 @default.
- W197702880 cites W1972758435 @default.
- W197702880 cites W1973023102 @default.
- W197702880 cites W1974275241 @default.
- W197702880 cites W1974912123 @default.
- W197702880 cites W1975326922 @default.
- W197702880 cites W1975638149 @default.
- W197702880 cites W1980435560 @default.
- W197702880 cites W1981967396 @default.
- W197702880 cites W1982283394 @default.
- W197702880 cites W1982846286 @default.
- W197702880 cites W1983855603 @default.
- W197702880 cites W1984120401 @default.
- W197702880 cites W1984159759 @default.
- W197702880 cites W1985554090 @default.
- W197702880 cites W1985881706 @default.
- W197702880 cites W1988836643 @default.
- W197702880 cites W1990975960 @default.
- W197702880 cites W1991300513 @default.
- W197702880 cites W1992365200 @default.
- W197702880 cites W1992763610 @default.
- W197702880 cites W1992795970 @default.
- W197702880 cites W1994093302 @default.
- W197702880 cites W1995056605 @default.
- W197702880 cites W1995201487 @default.
- W197702880 cites W1995313854 @default.
- W197702880 cites W1995504825 @default.
- W197702880 cites W1995761892 @default.
- W197702880 cites W1997406080 @default.
- W197702880 cites W1997872726 @default.
- W197702880 cites W1998584078 @default.
- W197702880 cites W2001214950 @default.
- W197702880 cites W2003128917 @default.
- W197702880 cites W2003345023 @default.
- W197702880 cites W2003660243 @default.
- W197702880 cites W2004035808 @default.
- W197702880 cites W2004445159 @default.
- W197702880 cites W2005382458 @default.
- W197702880 cites W2006127073 @default.
- W197702880 cites W2006772946 @default.
- W197702880 cites W2007803992 @default.
- W197702880 cites W2008670721 @default.
- W197702880 cites W2008958111 @default.
- W197702880 cites W2009134635 @default.
- W197702880 cites W2009164474 @default.
- W197702880 cites W2009447429 @default.
- W197702880 cites W2009821818 @default.
- W197702880 cites W2010299478 @default.
- W197702880 cites W2010700904 @default.
- W197702880 cites W2010856500 @default.
- W197702880 cites W2010924124 @default.
- W197702880 cites W2012698769 @default.
- W197702880 cites W2016056501 @default.
- W197702880 cites W2016972532 @default.
- W197702880 cites W2016983056 @default.
- W197702880 cites W2017068342 @default.
- W197702880 cites W2017549779 @default.
- W197702880 cites W2018482621 @default.
- W197702880 cites W2019291514 @default.
- W197702880 cites W2019953824 @default.
- W197702880 cites W2021092126 @default.
- W197702880 cites W2022522877 @default.
- W197702880 cites W2022854826 @default.
- W197702880 cites W2023520518 @default.
- W197702880 cites W2024330927 @default.
- W197702880 cites W2024562186 @default.
- W197702880 cites W2025878133 @default.
- W197702880 cites W2026194631 @default.
- W197702880 cites W2026210414 @default.
- W197702880 cites W2026378621 @default.
- W197702880 cites W2026723434 @default.
- W197702880 cites W2026804417 @default.
- W197702880 cites W2026812180 @default.
- W197702880 cites W2027517558 @default.