FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977029377> ?p ?o ?g. }

• W1977029377 abstract "A 24-mer (antisense) phosphorothioate oligonucleotide (ODN) corresponding to the codons 2-9 of the c-myb gene was evaluated for its effects on the growth of a human Burkitt lymphoma cell line (Raji) in vitro. Raji cells incubated with different concentrations of c-myb antisense ODN (5-15 mu g/ml) for 24-72 h showed a significant dose-dependent decrease in growth. The same concentrations of control (sense) or scrambled c-myb phosphorothioate ODNs did not inhibit Raji cell growth. The c-myb antisense ODN, but not the control ODNs, significantly decreased c-myb mRNA levels in treated cells as determined by RT-PCR. Additionally, the c-myb antisense ODN induced apoptosis of Raji cells as demonstrated by i) flow cytometry to enumerate the A(o) (apoptotic cell population) population of propidium iodide stained cells; ii) electron microscopy to evaluate the cell morphology; and iii) DNA fragmentation pattern. Thus, an antisense c-myb ODN causes significant growth inhibition of Burkitt lymphoma cells, and one mechanism of growth inhibition is the induction of apoptosis of the lymphoma cells. In addition, antisense c-myb ODN did not reduce CFU-GM or BFU-e colony-forming ability of normal hematopoietic stem/progenitor cells. Because the inhibition is sequence-specific and Burkitt lymphoma cell selective, evaluation of the therapeutic effects of c-myb antisense ODN against Burkitt lymphoma is warranted." @default.
• W1977029377 created "2016-06-24" @default.
• W1977029377 creator A5021845531 @default.
• W1977029377 creator A5023254583 @default.
• W1977029377 creator A5027071693 @default.
• W1977029377 creator A5042653357 @default.
• W1977029377 creator A5050455344 @default.
• W1977029377 creator A5058696788 @default.
• W1977029377 creator A5072414308 @default.
• W1977029377 creator A5082192456 @default.
• W1977029377 creator A5088904535 @default.
• W1977029377 creator A5089893290 @default.
• W1977029377 date "1996-04-01" @default.
• W1977029377 modified "2023-09-27" @default.
• W1977029377 title "Oligonucleotides complementary to c-myb messenger RNA inhibit growth and induce apoptosis in human Burkitt lymphoma cells" @default.
• W1977029377 doi "https://doi.org/10.3892/ijo.8.4.815" @default.
• W1977029377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21544432" @default.
• W1977029377 hasPublicationYear "1996" @default.
• W1977029377 type Work @default.
• W1977029377 sameAs 1977029377 @default.
• W1977029377 citedByCount "4" @default.
• W1977029377 countsByYear W19770293772019 @default.
• W1977029377 crossrefType "journal-article" @default.
• W1977029377 hasAuthorship W1977029377A5021845531 @default.
• W1977029377 hasAuthorship W1977029377A5023254583 @default.
• W1977029377 hasAuthorship W1977029377A5027071693 @default.
• W1977029377 hasAuthorship W1977029377A5042653357 @default.
• W1977029377 hasAuthorship W1977029377A5050455344 @default.
• W1977029377 hasAuthorship W1977029377A5058696788 @default.
• W1977029377 hasAuthorship W1977029377A5072414308 @default.
• W1977029377 hasAuthorship W1977029377A5082192456 @default.
• W1977029377 hasAuthorship W1977029377A5088904535 @default.
• W1977029377 hasAuthorship W1977029377A5089893290 @default.
• W1977029377 hasConcept C104317684 @default.
• W1977029377 hasConcept C144024400 @default.
• W1977029377 hasConcept C149923435 @default.
• W1977029377 hasConcept C150194340 @default.
• W1977029377 hasConcept C153911025 @default.
• W1977029377 hasConcept C16232356 @default.
• W1977029377 hasConcept C190283241 @default.
• W1977029377 hasConcept C202416437 @default.
• W1977029377 hasConcept C203014093 @default.
• W1977029377 hasConcept C2775934118 @default.
• W1977029377 hasConcept C2778913318 @default.
• W1977029377 hasConcept C2779338263 @default.
• W1977029377 hasConcept C2908647359 @default.
• W1977029377 hasConcept C29537977 @default.
• W1977029377 hasConcept C31573885 @default.
• W1977029377 hasConcept C502942594 @default.
• W1977029377 hasConcept C553184892 @default.
• W1977029377 hasConcept C55493867 @default.
• W1977029377 hasConcept C62112901 @default.
• W1977029377 hasConcept C86803240 @default.
• W1977029377 hasConceptScore W1977029377C104317684 @default.
• W1977029377 hasConceptScore W1977029377C144024400 @default.
• W1977029377 hasConceptScore W1977029377C149923435 @default.
• W1977029377 hasConceptScore W1977029377C150194340 @default.
• W1977029377 hasConceptScore W1977029377C153911025 @default.
• W1977029377 hasConceptScore W1977029377C16232356 @default.
• W1977029377 hasConceptScore W1977029377C190283241 @default.
• W1977029377 hasConceptScore W1977029377C202416437 @default.
• W1977029377 hasConceptScore W1977029377C203014093 @default.
• W1977029377 hasConceptScore W1977029377C2775934118 @default.
• W1977029377 hasConceptScore W1977029377C2778913318 @default.
• W1977029377 hasConceptScore W1977029377C2779338263 @default.
• W1977029377 hasConceptScore W1977029377C2908647359 @default.
• W1977029377 hasConceptScore W1977029377C29537977 @default.
• W1977029377 hasConceptScore W1977029377C31573885 @default.
• W1977029377 hasConceptScore W1977029377C502942594 @default.
• W1977029377 hasConceptScore W1977029377C553184892 @default.
• W1977029377 hasConceptScore W1977029377C55493867 @default.
• W1977029377 hasConceptScore W1977029377C62112901 @default.
• W1977029377 hasConceptScore W1977029377C86803240 @default.
• W1977029377 hasLocation W19770293771 @default.
• W1977029377 hasLocation W19770293772 @default.
• W1977029377 hasOpenAccess W1977029377 @default.
• W1977029377 hasPrimaryLocation W19770293771 @default.
• W1977029377 hasRelatedWork W1142727283 @default.
• W1977029377 hasRelatedWork W1564361044 @default.
• W1977029377 hasRelatedWork W1663050587 @default.
• W1977029377 hasRelatedWork W1990345772 @default.
• W1977029377 hasRelatedWork W2002031544 @default.
• W1977029377 hasRelatedWork W2005263819 @default.
• W1977029377 hasRelatedWork W2009328461 @default.
• W1977029377 hasRelatedWork W2046925094 @default.
• W1977029377 hasRelatedWork W2050397440 @default.
• W1977029377 hasRelatedWork W2091128862 @default.
• W1977029377 hasRelatedWork W2289813631 @default.
• W1977029377 hasRelatedWork W2318329525 @default.
• W1977029377 hasRelatedWork W2338130374 @default.
• W1977029377 hasRelatedWork W2359182792 @default.
• W1977029377 hasRelatedWork W2366294832 @default.
• W1977029377 hasRelatedWork W2370824328 @default.
• W1977029377 hasRelatedWork W2380678091 @default.
• W1977029377 hasRelatedWork W2393852377 @default.
• W1977029377 hasRelatedWork W2471500742 @default.
• W1977029377 hasRelatedWork W3147311132 @default.
• W1977029377 isParatext "false" @default.
• W1977029377 isRetracted "false" @default.
• W1977029377 magId "1977029377" @default.

• next