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- W1977044769 abstract "Man-made: This Focus Review describes the evolution of artificial proteases. The evolution took place though discovery of catalytic centers for peptide hydrolysis, attachment of substrate-recognition sites to the catalytic centers, and the advent of target-selective artificial proteases. Application of the target-selective artificial proteases led to a therapeutic option for amyloid diseases, such as Alzheimer's disease and diabetes. This Focus Review describes the evolution of artificial proteases, which are synthetic catalysts for peptide hydrolysis that mimic the action of natural proteases. The evolution took place through discovery of catalytic centers for peptide hydrolysis, attachment of substrate-recognition sites to the catalytic centers, and the advent of target-selective artificial proteases. Application of the target-selective artificial proteases led to a therapeutic option for amyloid diseases, such as Alzheimer’s disease and diabetes. 1" @default.
- W1977044769 created "2016-06-24" @default.
- W1977044769 creator A5041629005 @default.
- W1977044769 date "2013-10-11" @default.
- W1977044769 modified "2023-10-16" @default.
- W1977044769 title "Progress in Designing Artificial Proteases: A New Therapeutic Option for Amyloid Diseases" @default.
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- W1977044769 doi "https://doi.org/10.1002/ajoc.201300135" @default.
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