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• W1977054087 abstract "Recent study on the gas-phase binding of noncovalent protein complexes formed between bovine pancreatic trypsin inhibitor (BPTI) and its target enzymes by ESI-MS/MS revealed that interactions existing in the gas-phase are not reflective of their solution behavior [J. Mass Spectrom. 36 (2001) 950]. In the work described here, the question whether mass spectrometry evaluation of the solution binding properties of these noncovalent protein complexes are reflective of their solution-phase interactions was addressed. Assessment of the titration and competitive binding experiments from the abundance of gas-phase complex ions produced by an ESI source showed correlation with known solution binding order in relative, rather than in absolute, terms; suggesting disruption of the previously existing solution equilibrium. In addition, new data on the dissociation of the gas-phase ions of noncovalent protein complexes produced by nanoESI source were also acquired. These data were compared with previously published observations for dissociation of gas-phase ions of these noncovalent complexes produced by ESI source. Gas-phase binding of noncovalent protein complexes was assessed from the ease of dissociation of gas-phase ions using a collision model for an ion activation. It is shown that gas-phase ions of noncovalent protein complexes produced by both nano- and ESI sources have similar binding energies, however, different from that of the solution complexes, implying that the solution structure of these noncovalent protein complexes was not preserved in the gas-phase. Conclusions on the influence of the method chosen to study solution interactions on the outcome of investigation and comparison with previously reported observations were made." @default.
• W1977054087 created "2016-06-24" @default.
• W1977054087 creator A5067249718 @default.
• W1977054087 date "2002-11-01" @default.
• W1977054087 modified "2023-10-10" @default.
• W1977054087 title "Mass spectrometry evaluation of the solution and gas-phase binding properties of noncovalent protein complexes" @default.
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• W1977054087 doi "https://doi.org/10.1016/s1387-3806(02)00956-9" @default.
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