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- W1977061418 abstract "Novel phosphorylated derivatives of ribavirin 5-16 were synthesized by the reaction of 4-nitrophenyl phosphorodichloridate with various amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the intermediates 3. On further reaction of 3 with ribavirin in THF and pyridine in the presence of TEA afforded the title compounds 5-16. Their structures were characterized by IR, <TEX>$^1H$</TEX>, <TEX>$^{13}C$</TEX>, <TEX>$^{31}P$</TEX> NMR and mass spectral analyses. All the title compounds were found to exhibit potent in vitro anticancer activity against MCF-7 breast cancer cell lines." @default.
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- W1977061418 date "2011-12-20" @default.
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- W1977061418 title "Synthesis and Cytotoxicity Evaluation of Phosphorylated Derivatives of Ribavirin" @default.
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- W1977061418 doi "https://doi.org/10.5012/jkcs.2011.55.6.952" @default.
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