FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977064177> ?p ?o ?g. }

• W1977064177 endingPage "19" @default.
• W1977064177 startingPage "11" @default.
• W1977064177 abstract "There is available evidence supporting a positive association between alcohol intake and risk of breast cancer. However, there is limited information regarding possible mechanisms for this effect. Past studies from our laboratory suggest that acetaldehyde accumulation in mammary tissue after alcohol intake may be of particular relevance and that cytosolic and microsomal in situ bioactivation of ethanol to acetaldehyde and free radicals and the resulting stimulation of oxidative stress could be a significant early event related to tumor promotion. In the present studies repetitive alcohol drinking for 28 days was found to produce significant decreases in the mammary tissue content of GSH and alpha tocopherol and in glutathione S-transferase or glutathione reductase activities. In contrast, glutathione peroxidase activity was slightly increased. Malondialdehyde determinations did not show the occurrence of lipid peroxidation while the xylenol orange procedure gave positive results. The mammary microsomal metabolism of ethanol to acetaldehyde was not induced after an acute dose of ethanol or acetone able to induce the activity of its liver counterpart. The cytosolic pathway of alcohol metabolism instead was significantly enhanced by these two treatments. No increased generation of comet images was found either in mammary tissue or in liver under the experimental conditions tested. Results suggest that, while acetaldehyde accumulation in mammary tissue could be a critical event resulting from increasing production of acetaldehyde in situ plus an additional amount of it arriving via blood, other factors such as poor handling of the accumulated acetaldehyde could be also relevant. Copyright © 2010 John Wiley & Sons, Ltd." @default.
• W1977064177 created "2016-06-24" @default.
• W1977064177 creator A5012561202 @default.
• W1977064177 creator A5023193784 @default.
• W1977064177 creator A5024957681 @default.
• W1977064177 creator A5054601937 @default.
• W1977064177 creator A5065345321 @default.
• W1977064177 creator A5075754337 @default.
• W1977064177 creator A5090945054 @default.
• W1977064177 date "2010-12-23" @default.
• W1977064177 modified "2023-10-07" @default.
• W1977064177 title "Further studies on the potential contribution of acetaldehyde accumulation and oxidative stress in rat mammary tissue in the alcohol drinking promotion of breast cancer" @default.
• W1977064177 cites W1545899030 @default.
• W1977064177 cites W1546592314 @default.
• W1977064177 cites W1581414347 @default.
• W1977064177 cites W1915020749 @default.
• W1977064177 cites W1966159565 @default.
• W1977064177 cites W1966681919 @default.
• W1977064177 cites W1974053407 @default.
• W1977064177 cites W1980390662 @default.
• W1977064177 cites W1982705818 @default.
• W1977064177 cites W1995075995 @default.
• W1977064177 cites W2009692616 @default.
• W1977064177 cites W2011116144 @default.
• W1977064177 cites W2016366656 @default.
• W1977064177 cites W2023831287 @default.
• W1977064177 cites W2029665132 @default.
• W1977064177 cites W2031470075 @default.
• W1977064177 cites W2042149951 @default.
• W1977064177 cites W2043955239 @default.
• W1977064177 cites W2045849727 @default.
• W1977064177 cites W2046931774 @default.
• W1977064177 cites W2052234273 @default.
• W1977064177 cites W2054129051 @default.
• W1977064177 cites W2070308766 @default.
• W1977064177 cites W2070957122 @default.
• W1977064177 cites W2072387532 @default.
• W1977064177 cites W2083600400 @default.
• W1977064177 cites W2084479207 @default.
• W1977064177 cites W2086509529 @default.
• W1977064177 cites W2090502215 @default.
• W1977064177 cites W2098723642 @default.
• W1977064177 cites W2115500566 @default.
• W1977064177 cites W2121901561 @default.
• W1977064177 cites W2127775495 @default.
• W1977064177 cites W214196595 @default.
• W1977064177 cites W2144635719 @default.
• W1977064177 cites W2163278516 @default.
• W1977064177 cites W2163699185 @default.
• W1977064177 cites W2164551609 @default.
• W1977064177 cites W2166050484 @default.
• W1977064177 cites W2505783678 @default.
• W1977064177 cites W4250343777 @default.
• W1977064177 doi "https://doi.org/10.1002/jat.1555" @default.
• W1977064177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20623749" @default.
• W1977064177 hasPublicationYear "2010" @default.
• W1977064177 type Work @default.
• W1977064177 sameAs 1977064177 @default.
• W1977064177 citedByCount "23" @default.
• W1977064177 countsByYear W19770641772012 @default.
• W1977064177 countsByYear W19770641772014 @default.
• W1977064177 countsByYear W19770641772015 @default.
• W1977064177 countsByYear W19770641772016 @default.
• W1977064177 countsByYear W19770641772017 @default.
• W1977064177 countsByYear W19770641772019 @default.
• W1977064177 countsByYear W19770641772021 @default.
• W1977064177 countsByYear W19770641772022 @default.
• W1977064177 countsByYear W19770641772023 @default.
• W1977064177 crossrefType "journal-article" @default.
• W1977064177 hasAuthorship W1977064177A5012561202 @default.
• W1977064177 hasAuthorship W1977064177A5023193784 @default.
• W1977064177 hasAuthorship W1977064177A5024957681 @default.
• W1977064177 hasAuthorship W1977064177A5054601937 @default.
• W1977064177 hasAuthorship W1977064177A5065345321 @default.
• W1977064177 hasAuthorship W1977064177A5075754337 @default.
• W1977064177 hasAuthorship W1977064177A5090945054 @default.
• W1977064177 hasBestOaLocation W19770641771 @default.
• W1977064177 hasConcept C126322002 @default.
• W1977064177 hasConcept C134018914 @default.
• W1977064177 hasConcept C165069038 @default.
• W1977064177 hasConcept C181199279 @default.
• W1977064177 hasConcept C185592680 @default.
• W1977064177 hasConcept C2776151105 @default.
• W1977064177 hasConcept C2777595113 @default.
• W1977064177 hasConcept C2778401633 @default.
• W1977064177 hasConcept C2778760513 @default.
• W1977064177 hasConcept C2778979269 @default.
• W1977064177 hasConcept C2780161600 @default.
• W1977064177 hasConcept C2780829032 @default.
• W1977064177 hasConcept C2781066024 @default.
• W1977064177 hasConcept C30153976 @default.
• W1977064177 hasConcept C538909803 @default.
• W1977064177 hasConcept C55493867 @default.
• W1977064177 hasConcept C71924100 @default.
• W1977064177 hasConcept C86803240 @default.
• W1977064177 hasConceptScore W1977064177C126322002 @default.
• W1977064177 hasConceptScore W1977064177C134018914 @default.
• W1977064177 hasConceptScore W1977064177C165069038 @default.

• next