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- W1977064263 abstract "Bioassay-guided fractionation and purification of the anti-HIV-1-active MeOH extract from the leaves and twigs of Polyalthia sclerophylla led to the isolation of two new compounds, ent-kaur-sclerodimer (1) and cyclotucanol 3-palmitate (2), along with the known ent-kaur-16-en-19-oic acid (3), 15β-hydroxy-ent-kaur-16-en-19-oic acid (4), 15β-acetoxy-ent-kaur-16-en-19-oic acid (5), 15-oxo-ent-kaur-16-en-19-oic acid (6), 16α,17-dihydroxy-ent-kauran-19-oic acid (7), 16α-hydroxy-ent-kauran-19-oic acid (xylopic acid) (8), a pseudodimer (15α-hydroxy-ent-kaur-16-en-19-oic acid/17-hydroxy-ent-kaur-15-en-19-oic acid) (9), ermanin, nicotiflorin, and allantoin. Among these isolates, compound 3 was the most active in both anti-syncytium (EC50 13.7 µg/mL and selectivity index 3.1) and HIV-1 reverse transcriptase (IC50 34.1 µg/mL) assays." @default.
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- W1977064263 date "2009-12-14" @default.
- W1977064263 modified "2023-09-27" @default.
- W1977064263 title "Anti-HIV‐1 Diterpenoids from Leaves and Twigs of<i>Polyalthia sclerophylla</i>" @default.
- W1977064263 doi "https://doi.org/10.1055/s-0029-1240683" @default.
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