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• W1977071381 abstract "This study examined the possibility that a tonic activity in the endogenous opioid systems (EO systems) exists in animals under normal conditions. In a first set of experiments, concurrent changes in behavioral responses and in the numbers of c-Fos-like immunoreactive (Fos-LI) neurons in 58 structures of the brain and lumbosacral spinal cord were analyzed in rats after systemic administration of the opioid antagonist naloxone (NAL; 2 mg/kg). Possible roles of the EO systems were inferred from changes in the numbers of Fos-LI neurons between normal rats that received either NAL or the same volume of saline. Free-floating sections were processed immunohistochemically for c-Fos protein using standard avidin-biotin complex methods. After NAL, the numbers of Fos-LI neurons were significantly increased in the area postrema; in the caudal, intermediate, and rostral parts of the nucleus tractus solitarii; in the rostral ventrolateral medulla; in the Kölliker-Fuse nucleus; in the supramammillary nucleus; and in the central nucleus of the amygdala. In a second set of experiments examining changes in c-Fos expression in the latter structures, similar increases were found after NAL but not after an equimolar dose of NAL-methiodide, a preferential, peripherally acting opioid receptor antagonist. Therefore, Fos-LI was likely triggered after blockade of central opioid receptors, but not peripheral opioid receptors, releasing neurons from EO system-mediated inhibition. The results of this study suggest the existence of a tonic activity of the EO systems exerted on a restricted number of brain regions in normal rats. This tonic activity of the EO systems may control part of the neural networks involved in cardiorespiratory functions and in emotional and learning processes." @default.
• W1977071381 created "2016-06-24" @default.
• W1977071381 creator A5056963078 @default.
• W1977071381 creator A5072251378 @default.
• W1977071381 creator A5091794495 @default.
• W1977071381 date "2000-01-01" @default.
• W1977071381 modified "2023-10-05" @default.
• W1977071381 title "Is there tonic activity in the endogenous opioid systems? A c-Fos study in the rat central nervous system after intravenous injection of naloxone or naloxone-methiodide" @default.
• W1977071381 cites W1621805642 @default.
• W1977071381 cites W1920463507 @default.
• W1977071381 cites W1963571152 @default.
• W1977071381 cites W1963871594 @default.
• W1977071381 cites W1964863750 @default.
• W1977071381 cites W1966182087 @default.
• W1977071381 cites W1969553615 @default.
• W1977071381 cites W1972510034 @default.
• W1977071381 cites W1977493234 @default.
• W1977071381 cites W1980468946 @default.
• W1977071381 cites W1981373212 @default.
• W1977071381 cites W1983307075 @default.
• W1977071381 cites W1986630887 @default.
• W1977071381 cites W1992179844 @default.
• W1977071381 cites W1992296810 @default.
• W1977071381 cites W2004199815 @default.
• W1977071381 cites W2007495886 @default.
• W1977071381 cites W2008330001 @default.
• W1977071381 cites W2009855911 @default.
• W1977071381 cites W2011645297 @default.
• W1977071381 cites W2011909453 @default.
• W1977071381 cites W2015506510 @default.
• W1977071381 cites W2022597247 @default.
• W1977071381 cites W2024309411 @default.
• W1977071381 cites W2025414544 @default.
• W1977071381 cites W2027655628 @default.
• W1977071381 cites W2028097773 @default.
• W1977071381 cites W2031830498 @default.
• W1977071381 cites W2033986970 @default.
• W1977071381 cites W2034053403 @default.
• W1977071381 cites W2035294814 @default.
• W1977071381 cites W2037155998 @default.
• W1977071381 cites W2038334164 @default.
• W1977071381 cites W2038471978 @default.
• W1977071381 cites W2038691933 @default.
• W1977071381 cites W2038808393 @default.
• W1977071381 cites W2042729397 @default.
• W1977071381 cites W2042892319 @default.
• W1977071381 cites W2047383748 @default.
• W1977071381 cites W2048444518 @default.
• W1977071381 cites W2049647535 @default.
• W1977071381 cites W2050159235 @default.
• W1977071381 cites W2051741307 @default.
• W1977071381 cites W2057782867 @default.
• W1977071381 cites W2060583363 @default.
• W1977071381 cites W2063841737 @default.
• W1977071381 cites W2066126441 @default.
• W1977071381 cites W2066369835 @default.
• W1977071381 cites W2068773338 @default.
• W1977071381 cites W2069409350 @default.
• W1977071381 cites W2069739187 @default.
• W1977071381 cites W2070790512 @default.
• W1977071381 cites W2075776242 @default.
• W1977071381 cites W2075811628 @default.
• W1977071381 cites W2077165925 @default.
• W1977071381 cites W2082704208 @default.
• W1977071381 cites W2085579887 @default.
• W1977071381 cites W2086438600 @default.
• W1977071381 cites W2086571500 @default.
• W1977071381 cites W2089241827 @default.
• W1977071381 cites W2089272936 @default.
• W1977071381 cites W2089710352 @default.
• W1977071381 cites W2089813416 @default.
• W1977071381 cites W2091228509 @default.
• W1977071381 cites W2091497325 @default.
• W1977071381 cites W2092059755 @default.
• W1977071381 cites W2094037774 @default.
• W1977071381 cites W2098553579 @default.
• W1977071381 cites W2102632295 @default.
• W1977071381 cites W2107366093 @default.
• W1977071381 cites W2114382165 @default.
• W1977071381 cites W2127687530 @default.
• W1977071381 cites W2129365578 @default.
• W1977071381 cites W2138930132 @default.
• W1977071381 cites W2147170180 @default.
• W1977071381 cites W2172323892 @default.
• W1977071381 cites W2259173250 @default.
• W1977071381 cites W2323536904 @default.
• W1977071381 cites W2464530791 @default.
• W1977071381 cites W27551127 @default.
• W1977071381 cites W4244037513 @default.
• W1977071381 cites W4252229951 @default.
• W1977071381 cites W4296759742 @default.
• W1977071381 doi "https://doi.org/10.1002/1096-9861(20001113)427:2<285::aid-cne9>3.0.co;2-t" @default.
• W1977071381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11054694" @default.
• W1977071381 hasPublicationYear "2000" @default.
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