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• W1977081887 abstract "Thiostrepton and micrococcin inhibit protein synthesis by binding to the L11 binding domain (L11BD) of 23S ribosomal RNA. The two compounds are structurally related, yet they produce different effects on ribosomal RNA in footprinting experiments and on elongation factor-G (EF-G)-dependent GTP hydrolysis. Using NMR and an assay based on A1067 methylation by thiostrepton-resistance methyltransferase, we show that the related thiazoles, nosiheptide and siomycin, also bind to this region. The effect of all four antibiotics on EF-G-dependent GTP hydrolysis and EF-G-GDP-ribosome complex formation was studied. Our NMR and biochemical data demonstrate that thiostrepton, nosiheptide, and siomycin share a common profile, which differs from that of micrococcin. We have generated a three-dimensional (3D) model for the interaction of thiostrepton with L11BD RNA. The model rationalizes the differences between micrococcin and the thiostrepton-like antibiotics interacting with L11BD." @default.
• W1977081887 created "2016-06-24" @default.
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• W1977081887 date "2003-08-01" @default.
• W1977081887 modified "2023-10-14" @default.
• W1977081887 title "Structural Basis for Contrasting Activities of Ribosome Binding Thiazole Antibiotics" @default.
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• W1977081887 doi "https://doi.org/10.1016/s1074-5521(03)00173-x" @default.
• W1977081887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12954336" @default.
• W1977081887 hasPublicationYear "2003" @default.
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