Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977082334> ?p ?o ?g. }
- W1977082334 endingPage "166" @default.
- W1977082334 startingPage "161" @default.
- W1977082334 abstract "Osteoarthritis of the knee has consistently been linked to obesity, defined as a body mass index (BMI) >30 kg/m2. It has been hypothesized that obesity may lead to osteoarthritis through increased joint pressure, accumulated microtrauma, and disruption of normal chondrocyte metabolism. These changes in chondrocyte metabolism have not been thoroughly investigated, and it is the purpose of this study to identify a relationship between BMI and altered chondrocyte metabolism in osteoarthritic tissue. Articular cartilage was harvested from the femoral condyles of patients after total knee arthroplasty, and analyzed in explant and alginate models. Glycosaminoglycan (GAG) content was measured using a dimethylmethylene blue assay and normalized to DNA content using a PicoGreen® assay. Studies have reported GAGs to be a reliable measurement of chondrocyte metabolism and osteoarthritis progression. Our results show a significant linear relationship of increasing BMI and increasing GAG content in both alginate and explant models (p<0.001 and p=0.001). Obese (BMI≥30 kg/m2) and non-obese (BMI<30 kg/m2) comparisons also demonstrated significant differences with higher GAG/DNA content in obese individuals compared to non-obese (p=0.001 and p=0.015). The study results reveal significant relationships between GAG content and BMI in this population of osteoarthritic patients. The significant difference in GAG content between the obese and non-obese patients supports the connection between osteoarthritis and obesity previously reported. Higher patient BMI (>30 kg/m2) may be similar to dynamic compression injuries which cause increased GAG synthesis in response to cartilage damage." @default.
- W1977082334 created "2016-06-24" @default.
- W1977082334 creator A5007698239 @default.
- W1977082334 creator A5013097491 @default.
- W1977082334 creator A5027850382 @default.
- W1977082334 creator A5030489074 @default.
- W1977082334 creator A5030531024 @default.
- W1977082334 creator A5041863942 @default.
- W1977082334 creator A5055441218 @default.
- W1977082334 creator A5091881347 @default.
- W1977082334 date "2010-03-01" @default.
- W1977082334 modified "2023-09-26" @default.
- W1977082334 title "Metabolic activity of osteoarthritic knees correlates with BMI" @default.
- W1977082334 cites W104872243 @default.
- W1977082334 cites W1617781531 @default.
- W1977082334 cites W1964189028 @default.
- W1977082334 cites W1973937375 @default.
- W1977082334 cites W1980223350 @default.
- W1977082334 cites W1993806929 @default.
- W1977082334 cites W2002201489 @default.
- W1977082334 cites W2032255522 @default.
- W1977082334 cites W2034201007 @default.
- W1977082334 cites W2037178326 @default.
- W1977082334 cites W2051165214 @default.
- W1977082334 cites W2053999722 @default.
- W1977082334 cites W2054671841 @default.
- W1977082334 cites W2083631718 @default.
- W1977082334 cites W2090464741 @default.
- W1977082334 cites W2094460226 @default.
- W1977082334 cites W2094670200 @default.
- W1977082334 cites W2099285233 @default.
- W1977082334 cites W2102181510 @default.
- W1977082334 cites W2102308673 @default.
- W1977082334 cites W2105994280 @default.
- W1977082334 cites W2126882976 @default.
- W1977082334 cites W2128882188 @default.
- W1977082334 cites W2129544571 @default.
- W1977082334 cites W2130080922 @default.
- W1977082334 cites W2138009747 @default.
- W1977082334 cites W2142251176 @default.
- W1977082334 cites W2143908097 @default.
- W1977082334 cites W2157540502 @default.
- W1977082334 cites W3025829724 @default.
- W1977082334 cites W345774991 @default.
- W1977082334 cites W4292542165 @default.
- W1977082334 doi "https://doi.org/10.1016/j.knee.2009.07.012" @default.
- W1977082334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19729313" @default.
- W1977082334 hasPublicationYear "2010" @default.
- W1977082334 type Work @default.
- W1977082334 sameAs 1977082334 @default.
- W1977082334 citedByCount "11" @default.
- W1977082334 countsByYear W19770823342012 @default.
- W1977082334 countsByYear W19770823342013 @default.
- W1977082334 countsByYear W19770823342014 @default.
- W1977082334 countsByYear W19770823342015 @default.
- W1977082334 countsByYear W19770823342017 @default.
- W1977082334 countsByYear W19770823342018 @default.
- W1977082334 countsByYear W19770823342021 @default.
- W1977082334 crossrefType "journal-article" @default.
- W1977082334 hasAuthorship W1977082334A5007698239 @default.
- W1977082334 hasAuthorship W1977082334A5013097491 @default.
- W1977082334 hasAuthorship W1977082334A5027850382 @default.
- W1977082334 hasAuthorship W1977082334A5030489074 @default.
- W1977082334 hasAuthorship W1977082334A5030531024 @default.
- W1977082334 hasAuthorship W1977082334A5041863942 @default.
- W1977082334 hasAuthorship W1977082334A5055441218 @default.
- W1977082334 hasAuthorship W1977082334A5091881347 @default.
- W1977082334 hasConcept C105702510 @default.
- W1977082334 hasConcept C126322002 @default.
- W1977082334 hasConcept C134018914 @default.
- W1977082334 hasConcept C141071460 @default.
- W1977082334 hasConcept C142724271 @default.
- W1977082334 hasConcept C153074725 @default.
- W1977082334 hasConcept C198451711 @default.
- W1977082334 hasConcept C204787440 @default.
- W1977082334 hasConcept C2776164576 @default.
- W1977082334 hasConcept C2780221984 @default.
- W1977082334 hasConcept C2780550940 @default.
- W1977082334 hasConcept C2781403057 @default.
- W1977082334 hasConcept C2908647359 @default.
- W1977082334 hasConcept C511355011 @default.
- W1977082334 hasConcept C68312169 @default.
- W1977082334 hasConcept C71924100 @default.
- W1977082334 hasConcept C99454951 @default.
- W1977082334 hasConceptScore W1977082334C105702510 @default.
- W1977082334 hasConceptScore W1977082334C126322002 @default.
- W1977082334 hasConceptScore W1977082334C134018914 @default.
- W1977082334 hasConceptScore W1977082334C141071460 @default.
- W1977082334 hasConceptScore W1977082334C142724271 @default.
- W1977082334 hasConceptScore W1977082334C153074725 @default.
- W1977082334 hasConceptScore W1977082334C198451711 @default.
- W1977082334 hasConceptScore W1977082334C204787440 @default.
- W1977082334 hasConceptScore W1977082334C2776164576 @default.
- W1977082334 hasConceptScore W1977082334C2780221984 @default.
- W1977082334 hasConceptScore W1977082334C2780550940 @default.
- W1977082334 hasConceptScore W1977082334C2781403057 @default.
- W1977082334 hasConceptScore W1977082334C2908647359 @default.
- W1977082334 hasConceptScore W1977082334C511355011 @default.