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• W1977097874 abstract "□ Poly (methyl [l-14C]methacrylate) nanoparticles were injected subcutaneously into rats. Almost all of the radioactivity stayed at the injection site. After an initial urinary and fecal excretion of ~1% of the administered dose per day, the rate of elimination dropped to a low level (~0.005%/day via the feces and ~0.0005%/day via the urine) within 70 days. After 200 days, the fecal elimination increased exponentially until a>100-fold increase was observed after 287 days in one rat. After this time, a tendency for an increase in fecal elimination was also observed in the other animals, and the radioactivity in all organs and tissue increased by ~100 times in all animals in comparison with the organ radioactivity determinations at earlier times." @default.
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• W1977097874 date "1983-10-01" @default.
• W1977097874 modified "2023-10-10" @default.
• W1977097874 title "Distribution and Elimination of Poly (methyl methacrylate) Nanoparticles After Subcutaneous Administration to Rats" @default.
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• W1977097874 doi "https://doi.org/10.1002/jps.2600721009" @default.
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