FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977106004> ?p ?o ?g. }

• W1977106004 endingPage "204" @default.
• W1977106004 startingPage "185" @default.
• W1977106004 abstract "Over the past fifty years a significant body of evidence has been compiled suggesting an interaction between the endocannabinoid (EC) system and alcohol dependence. However, much of this work has been conducted only in the past two decades following the elucidation of the molecular constituents of the EC system that began with the serendipitous discovery of the cannabinoid 1 receptor (CB1). Since then, novel pharmacological and genetic tools have enabled researchers to manipulate select components of the EC system, to determine their contribution to the motivation to consume ethanol. From these preclinical studies, it is evident that CB1 contributes the motivational and reinforcing properties of ethanol, and chronic consumption of ethanol alters EC transmitter levels and CB1 expression in brain nuclei associated with addiction pathways. These results are augmented by in vitro and ex vivo studies showing that acute and chronic treatment with ethanol produces physiologically relevant alterations in the function of the EC system. This report provides a current and comprehensive review of the literature regarding the interactions between ethanol and the EC system. We begin be reviewing the studies published prior to the discovery of the EC system that compared the behavioral and physiological effects of cannabinoids with ethanol in addition to cross-tolerance between these drugs. Next, a brief overview of the molecular constituents of the EC system is provided as context for the subsequent review of more recent studies examining the interaction of ethanol with the EC system. These results are compiled into a summary providing a scheme for the known changes to the components of the EC system in different stages of alcohol dependence. Finally, future directions for research are discussed." @default.
• W1977106004 created "2016-06-24" @default.
• W1977106004 creator A5025957808 @default.
• W1977106004 creator A5081525770 @default.
• W1977106004 date "2012-05-01" @default.
• W1977106004 modified "2023-10-06" @default.
• W1977106004 title "A review of the interactions between alcohol and the endocannabinoid system: Implications for alcohol dependence and future directions for research" @default.
• W1977106004 cites W1498046084 @default.
• W1977106004 cites W1506924128 @default.
• W1977106004 cites W1522257677 @default.
• W1977106004 cites W1525686546 @default.
• W1977106004 cites W1534942440 @default.
• W1977106004 cites W1542528083 @default.
• W1977106004 cites W1581880761 @default.
• W1977106004 cites W1591647183 @default.
• W1977106004 cites W1592286181 @default.
• W1977106004 cites W1593697757 @default.
• W1977106004 cites W1597171929 @default.
• W1977106004 cites W1654380405 @default.
• W1977106004 cites W1787727230 @default.
• W1977106004 cites W1845377771 @default.
• W1977106004 cites W1876729781 @default.
• W1977106004 cites W1882675476 @default.
• W1977106004 cites W1945938111 @default.
• W1977106004 cites W1946254204 @default.
• W1977106004 cites W1964748906 @default.
• W1977106004 cites W1965331071 @default.
• W1977106004 cites W1965454986 @default.
• W1977106004 cites W1968039438 @default.
• W1977106004 cites W1968205004 @default.
• W1977106004 cites W1969338731 @default.
• W1977106004 cites W1970090145 @default.
• W1977106004 cites W1972144997 @default.
• W1977106004 cites W1972192503 @default.
• W1977106004 cites W1972428815 @default.
• W1977106004 cites W1973560063 @default.
• W1977106004 cites W1974462296 @default.
• W1977106004 cites W1975395507 @default.
• W1977106004 cites W1975891687 @default.
• W1977106004 cites W1976416429 @default.
• W1977106004 cites W1976693868 @default.
• W1977106004 cites W1978273243 @default.
• W1977106004 cites W1978767285 @default.
• W1977106004 cites W1978889063 @default.
• W1977106004 cites W1980272504 @default.
• W1977106004 cites W1980281942 @default.
• W1977106004 cites W1980718841 @default.
• W1977106004 cites W1981339796 @default.
• W1977106004 cites W1981964580 @default.
• W1977106004 cites W1984247449 @default.
• W1977106004 cites W1986404316 @default.
• W1977106004 cites W1988252572 @default.
• W1977106004 cites W1988860179 @default.
• W1977106004 cites W1989073099 @default.
• W1977106004 cites W1989463851 @default.
• W1977106004 cites W1989542650 @default.
• W1977106004 cites W1989756472 @default.
• W1977106004 cites W1995698614 @default.
• W1977106004 cites W1997128892 @default.
• W1977106004 cites W1997257847 @default.
• W1977106004 cites W1997374895 @default.
• W1977106004 cites W2000488780 @default.
• W1977106004 cites W2000809493 @default.
• W1977106004 cites W2001691002 @default.
• W1977106004 cites W2002511621 @default.
• W1977106004 cites W2003448950 @default.
• W1977106004 cites W2004019101 @default.
• W1977106004 cites W2006280591 @default.
• W1977106004 cites W2006295679 @default.
• W1977106004 cites W2006554061 @default.
• W1977106004 cites W2006842834 @default.
• W1977106004 cites W2010739745 @default.
• W1977106004 cites W2013010413 @default.
• W1977106004 cites W2015109725 @default.
• W1977106004 cites W2019101826 @default.
• W1977106004 cites W2021211846 @default.
• W1977106004 cites W2021332276 @default.
• W1977106004 cites W2023771224 @default.
• W1977106004 cites W2024122340 @default.
• W1977106004 cites W2024653583 @default.
• W1977106004 cites W2025367112 @default.
• W1977106004 cites W2025543167 @default.
• W1977106004 cites W2026556661 @default.
• W1977106004 cites W2027359943 @default.
• W1977106004 cites W2030129723 @default.
• W1977106004 cites W2030423682 @default.
• W1977106004 cites W2031117153 @default.
• W1977106004 cites W2031322724 @default.
• W1977106004 cites W2031873745 @default.
• W1977106004 cites W2032888644 @default.
• W1977106004 cites W2032969074 @default.
• W1977106004 cites W2033381049 @default.
• W1977106004 cites W2035073429 @default.
• W1977106004 cites W2035258383 @default.
• W1977106004 cites W2035400942 @default.
• W1977106004 cites W2035768389 @default.
• W1977106004 cites W2036055518 @default.
• W1977106004 cites W2038759626 @default.

• next