FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977107344> ?p ?o ?g. }

• W1977107344 endingPage "52" @default.
• W1977107344 startingPage "45" @default.
• W1977107344 abstract "Aims: Insulin analogues are widely used but few data exist comparing different analogue regimens. We compared two such regimens in type 2 diabetes mellitus (T2DM) uncontrolled by oral antidiabetic agents (OADs) with or without basal insulin. Methods: In a 26‐week multinational, multicentre, randomized treat‐to‐target trial, OADs were discontinued and subjects randomized to analogue basal–bolus therapy (insulin detemir once daily and insulin aspart mealtimes) or biphasic insulin aspart 30 (30% rapid‐acting insulin aspart), twice daily. Insulin was titrated to targets for fasting, predinner and postprandial plasma glucose (PG), as appropriate. Results: Of 719 subjects, 92% completed the study; 58% achieved haemoglobin fraction A 1c (HbA 1c ) ≤7.0%, with reductions of 1.56% (to 6.96%) with basal–bolus therapy and 1.23% (to 7.17%) with biphasic insulin aspart. Reduction with basal–bolus therapy was superior in the overall population by 0.23% (p = 0.0052), with no difference between regimens in insulin‐naive patients. Major hypoglycaemia occurred in five basal–bolus patients (0.9%) and in no patients with biphasic insulin aspart. Incidence of minor hypoglycaemia was similar in both groups. All insulin doses increased during titration, with increase in lunchtime insulin aspart dose and equal distribution of breakfast and dinner biphasic insulin aspart doses. Insulin detemir remained once daily in 87% of patients. Conclusions: Modern insulin analogue regimens, adjusted to PG targets, enable a majority of people with T2DM to reach HbA 1c ≤7.0% after failure of OADs and OAD‐basal insulin therapy. Insulin‐treated patients may benefit more from transfer to analogue basal–bolus therapy, while insulin‐naive individuals benefit equally well from the more convenient biphasic analogue regimen." @default.
• W1977107344 created "2016-06-24" @default.
• W1977107344 creator A5031742996 @default.
• W1977107344 creator A5034096266 @default.
• W1977107344 creator A5034967151 @default.
• W1977107344 creator A5055936518 @default.
• W1977107344 creator A5074260683 @default.
• W1977107344 creator A5083151910 @default.
• W1977107344 date "2008-12-22" @default.
• W1977107344 modified "2023-10-13" @default.
• W1977107344 title "Comparison of insulin analogue regimens in people with type 2 diabetes mellitus in the PREFER Study: a randomized controlled trial" @default.
• W1977107344 cites W1972763818 @default.
• W1977107344 cites W1983639156 @default.
• W1977107344 cites W1996580481 @default.
• W1977107344 cites W2007605927 @default.
• W1977107344 cites W2013495500 @default.
• W1977107344 cites W2049885152 @default.
• W1977107344 cites W2053398017 @default.
• W1977107344 cites W2065443996 @default.
• W1977107344 cites W2065690835 @default.
• W1977107344 cites W2079629654 @default.
• W1977107344 cites W2108769987 @default.
• W1977107344 cites W2111938541 @default.
• W1977107344 cites W2114369760 @default.
• W1977107344 cites W2123946565 @default.
• W1977107344 cites W2125788080 @default.
• W1977107344 cites W2129121181 @default.
• W1977107344 cites W2134664501 @default.
• W1977107344 cites W2136164787 @default.
• W1977107344 cites W2138181294 @default.
• W1977107344 cites W2141452626 @default.
• W1977107344 cites W2149194615 @default.
• W1977107344 doi "https://doi.org/10.1111/j.1463-1326.2008.00915.x" @default.
• W1977107344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18643839" @default.
• W1977107344 hasPublicationYear "2008" @default.
• W1977107344 type Work @default.
• W1977107344 sameAs 1977107344 @default.
• W1977107344 citedByCount "140" @default.
• W1977107344 countsByYear W19771073442012 @default.
• W1977107344 countsByYear W19771073442013 @default.
• W1977107344 countsByYear W19771073442014 @default.
• W1977107344 countsByYear W19771073442015 @default.
• W1977107344 countsByYear W19771073442016 @default.
• W1977107344 countsByYear W19771073442017 @default.
• W1977107344 countsByYear W19771073442018 @default.
• W1977107344 countsByYear W19771073442019 @default.
• W1977107344 countsByYear W19771073442020 @default.
• W1977107344 countsByYear W19771073442021 @default.
• W1977107344 countsByYear W19771073442022 @default.
• W1977107344 countsByYear W19771073442023 @default.
• W1977107344 crossrefType "journal-article" @default.
• W1977107344 hasAuthorship W1977107344A5031742996 @default.
• W1977107344 hasAuthorship W1977107344A5034096266 @default.
• W1977107344 hasAuthorship W1977107344A5034967151 @default.
• W1977107344 hasAuthorship W1977107344A5055936518 @default.
• W1977107344 hasAuthorship W1977107344A5074260683 @default.
• W1977107344 hasAuthorship W1977107344A5083151910 @default.
• W1977107344 hasConcept C126322002 @default.
• W1977107344 hasConcept C134018914 @default.
• W1977107344 hasConcept C168563851 @default.
• W1977107344 hasConcept C2778024521 @default.
• W1977107344 hasConcept C2778199505 @default.
• W1977107344 hasConcept C2779306644 @default.
• W1977107344 hasConcept C2779908123 @default.
• W1977107344 hasConcept C2779920387 @default.
• W1977107344 hasConcept C2780668416 @default.
• W1977107344 hasConcept C2780677441 @default.
• W1977107344 hasConcept C2781232474 @default.
• W1977107344 hasConcept C2908647359 @default.
• W1977107344 hasConcept C2910068830 @default.
• W1977107344 hasConcept C43376680 @default.
• W1977107344 hasConcept C555293320 @default.
• W1977107344 hasConcept C71924100 @default.
• W1977107344 hasConcept C99454951 @default.
• W1977107344 hasConceptScore W1977107344C126322002 @default.
• W1977107344 hasConceptScore W1977107344C134018914 @default.
• W1977107344 hasConceptScore W1977107344C168563851 @default.
• W1977107344 hasConceptScore W1977107344C2778024521 @default.
• W1977107344 hasConceptScore W1977107344C2778199505 @default.
• W1977107344 hasConceptScore W1977107344C2779306644 @default.
• W1977107344 hasConceptScore W1977107344C2779908123 @default.
• W1977107344 hasConceptScore W1977107344C2779920387 @default.
• W1977107344 hasConceptScore W1977107344C2780668416 @default.
• W1977107344 hasConceptScore W1977107344C2780677441 @default.
• W1977107344 hasConceptScore W1977107344C2781232474 @default.
• W1977107344 hasConceptScore W1977107344C2908647359 @default.
• W1977107344 hasConceptScore W1977107344C2910068830 @default.
• W1977107344 hasConceptScore W1977107344C43376680 @default.
• W1977107344 hasConceptScore W1977107344C555293320 @default.
• W1977107344 hasConceptScore W1977107344C71924100 @default.
• W1977107344 hasConceptScore W1977107344C99454951 @default.
• W1977107344 hasIssue "1" @default.
• W1977107344 hasLocation W19771073441 @default.
• W1977107344 hasLocation W19771073442 @default.
• W1977107344 hasOpenAccess W1977107344 @default.
• W1977107344 hasPrimaryLocation W19771073441 @default.
• W1977107344 hasRelatedWork W1979091213 @default.
• W1977107344 hasRelatedWork W2001097049 @default.

• next