FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977107900> ?p ?o ?g. }

• W1977107900 endingPage "740" @default.
• W1977107900 startingPage "735" @default.
• W1977107900 abstract "Sperm-mediated gene transfer (SMGT) is a procedure through which new genetic traits are introduced in animals by exploiting the ability of spermatozoa to take up exogenous DNA molecules and deliver them to oocytes at fertilization. The interaction of exogenous DNA with sperm cells is a regulated process mediated by specific factors; among those, a reverse transcriptase (RT) activity plays a central role in SMGT. 'Retro-genes' are generated either through reverse transcription of exogenous RNA internalized in spermatozoa, or through sequential transcription, splicing and reverse transcription of exogenous DNA. The resulting retro-genes are delivered to oocytes and transmitted to embryos and born animals as low-copy, transcriptionally competent, extrachromosomal structures capable of determining new phenotypic traits. Retro-genes can be further transmitted through sexual reproduction from founders to their F1 progeny: new genetic and phenotypic features, unlinked to chromosomes, can thus be generated and inherited in a non-Mendelian ratio. We have called this phenomenon sperm-mediated 'reverse' gene transfer (SMRGT). Thus, a RT-mediated machinery operates in sperm cells and is responsible for the genesis and non-Mendelian propagation of new genetic information. The features of RT-generated traits elicited in SMRGT resemble those characterized in recent studies of RNA-mediated inheritance of extra-genomic information." @default.
• W1977107900 created "2016-06-24" @default.
• W1977107900 creator A5027416476 @default.
• W1977107900 date "2008-01-31" @default.
• W1977107900 modified "2023-09-29" @default.
• W1977107900 title "Sperm-mediated 'reverse' gene transfer: a role of reverse transcriptase in the generation of new genetic information" @default.
• W1977107900 cites W1487878375 @default.
• W1977107900 cites W1523313546 @default.
• W1977107900 cites W1555887143 @default.
• W1977107900 cites W1572202589 @default.
• W1977107900 cites W1949465845 @default.
• W1977107900 cites W1964868648 @default.
• W1977107900 cites W1965884341 @default.
• W1977107900 cites W1969067527 @default.
• W1977107900 cites W1973879730 @default.
• W1977107900 cites W1993360890 @default.
• W1977107900 cites W2003918704 @default.
• W1977107900 cites W2003990216 @default.
• W1977107900 cites W2008122642 @default.
• W1977107900 cites W2008177392 @default.
• W1977107900 cites W2011213056 @default.
• W1977107900 cites W2014265027 @default.
• W1977107900 cites W2020795829 @default.
• W1977107900 cites W2035074912 @default.
• W1977107900 cites W2047939916 @default.
• W1977107900 cites W2050323940 @default.
• W1977107900 cites W2053508758 @default.
• W1977107900 cites W2054236386 @default.
• W1977107900 cites W2058614427 @default.
• W1977107900 cites W2067667474 @default.
• W1977107900 cites W2068517314 @default.
• W1977107900 cites W2073035527 @default.
• W1977107900 cites W2075639014 @default.
• W1977107900 cites W2075992913 @default.
• W1977107900 cites W2077156813 @default.
• W1977107900 cites W2082061523 @default.
• W1977107900 cites W2087631694 @default.
• W1977107900 cites W2095461413 @default.
• W1977107900 cites W2110362275 @default.
• W1977107900 cites W2123480171 @default.
• W1977107900 cites W2128526635 @default.
• W1977107900 cites W2146090990 @default.
• W1977107900 cites W2147332392 @default.
• W1977107900 cites W2149962584 @default.
• W1977107900 cites W2150649207 @default.
• W1977107900 cites W2160064083 @default.
• W1977107900 cites W2164898434 @default.
• W1977107900 cites W2168909179 @default.
• W1977107900 cites W2171660278 @default.
• W1977107900 cites W2186081755 @default.
• W1977107900 cites W4241911118 @default.
• W1977107900 doi "https://doi.org/10.1093/humrep/dem425" @default.
• W1977107900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18270183" @default.
• W1977107900 hasPublicationYear "2008" @default.
• W1977107900 type Work @default.
• W1977107900 sameAs 1977107900 @default.
• W1977107900 citedByCount "63" @default.
• W1977107900 countsByYear W19771079002012 @default.
• W1977107900 countsByYear W19771079002013 @default.
• W1977107900 countsByYear W19771079002014 @default.
• W1977107900 countsByYear W19771079002015 @default.
• W1977107900 countsByYear W19771079002016 @default.
• W1977107900 countsByYear W19771079002017 @default.
• W1977107900 countsByYear W19771079002018 @default.
• W1977107900 countsByYear W19771079002019 @default.
• W1977107900 countsByYear W19771079002020 @default.
• W1977107900 countsByYear W19771079002022 @default.
• W1977107900 countsByYear W19771079002023 @default.
• W1977107900 crossrefType "journal-article" @default.
• W1977107900 hasAuthorship W1977107900A5027416476 @default.
• W1977107900 hasConcept C104317684 @default.
• W1977107900 hasConcept C141231307 @default.
• W1977107900 hasConcept C156719811 @default.
• W1977107900 hasConcept C182420341 @default.
• W1977107900 hasConcept C2781087480 @default.
• W1977107900 hasConcept C54355233 @default.
• W1977107900 hasConcept C54458228 @default.
• W1977107900 hasConcept C67705224 @default.
• W1977107900 hasConcept C86803240 @default.
• W1977107900 hasConcept C89684784 @default.
• W1977107900 hasConceptScore W1977107900C104317684 @default.
• W1977107900 hasConceptScore W1977107900C141231307 @default.
• W1977107900 hasConceptScore W1977107900C156719811 @default.
• W1977107900 hasConceptScore W1977107900C182420341 @default.
• W1977107900 hasConceptScore W1977107900C2781087480 @default.
• W1977107900 hasConceptScore W1977107900C54355233 @default.
• W1977107900 hasConceptScore W1977107900C54458228 @default.
• W1977107900 hasConceptScore W1977107900C67705224 @default.
• W1977107900 hasConceptScore W1977107900C86803240 @default.
• W1977107900 hasConceptScore W1977107900C89684784 @default.
• W1977107900 hasIssue "4" @default.
• W1977107900 hasLocation W19771079001 @default.
• W1977107900 hasLocation W19771079002 @default.
• W1977107900 hasOpenAccess W1977107900 @default.
• W1977107900 hasPrimaryLocation W19771079001 @default.
• W1977107900 hasRelatedWork W1991523530 @default.
• W1977107900 hasRelatedWork W2002128513 @default.
• W1977107900 hasRelatedWork W2008704455 @default.

• next