Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977126789> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W1977126789 abstract "PURPOSE: Jobelyn® is a commercial herbal product recommended for the management of anemia related illnesses. Despite its wide use, there is limited report on its toxicological profile. This study examined the acute and shortterm chronic toxicity profiles of the product with emphasis on the LD50, gross morphological and histopathological effects. METHODS: Albino mice (mean weight: 16.45±3.14g) were used in this study. For acute toxicity, graded concentrations of Jobelyn® were administered orally and intraperitoneally as single doses to the mice. Intraperitoneal administration of sub-lethal doses daily for 14 days was adopted for the shortterm chronic toxicity studies. RESULTS: The LD50 following oral and intraperitoneal administration were 215.06 mg/kg (r = 0.916) and 193.37 mg/kg (r = 0.995), respectively. The major behavioral/ morphological effects at high doses were reduction in motor activity, piloerection and sedation. The sub-lethal doses did not significantly modify the normal behavioral repertoire of licking, grooming and sniffing. Histopathological examination also did not indicate severe pathological changes. At the lethal doses, some degree of congestion was noticed in the lung, liver splenic and kidney tissues. Short-term chronic studies did not produce further toxic effects but transient mild sedation and piloerection and histopathological examination revealed only mild congestion in the organs. No death of the animals was recorded during the period of sub-chronic toxicity assessment. CONCLUSION: Jobelyn® is likely to be safe for use in humans when administered at recommended doses. Keywords: Jobelyn, safety profile, LD50, toxicity" @default.
- W1977126789 created "2016-06-24" @default.
- W1977126789 creator A5027970987 @default.
- W1977126789 creator A5056372153 @default.
- W1977126789 date "2010-06-10" @default.
- W1977126789 modified "2023-10-17" @default.
- W1977126789 title "Toxicological profiles of commercial herbal preparation, Jobelyn" @default.
- W1977126789 doi "https://doi.org/10.4314/ijhr.v2i4.55438" @default.
- W1977126789 hasPublicationYear "2010" @default.
- W1977126789 type Work @default.
- W1977126789 sameAs 1977126789 @default.
- W1977126789 citedByCount "3" @default.
- W1977126789 countsByYear W19771267892013 @default.
- W1977126789 countsByYear W19771267892017 @default.
- W1977126789 countsByYear W19771267892022 @default.
- W1977126789 crossrefType "journal-article" @default.
- W1977126789 hasAuthorship W1977126789A5027970987 @default.
- W1977126789 hasAuthorship W1977126789A5056372153 @default.
- W1977126789 hasBestOaLocation W19771267891 @default.
- W1977126789 hasConcept C116263406 @default.
- W1977126789 hasConcept C126322002 @default.
- W1977126789 hasConcept C142724271 @default.
- W1977126789 hasConcept C167552308 @default.
- W1977126789 hasConcept C2780723003 @default.
- W1977126789 hasConcept C29730261 @default.
- W1977126789 hasConcept C3020547009 @default.
- W1977126789 hasConcept C53164099 @default.
- W1977126789 hasConcept C71924100 @default.
- W1977126789 hasConcept C98274493 @default.
- W1977126789 hasConceptScore W1977126789C116263406 @default.
- W1977126789 hasConceptScore W1977126789C126322002 @default.
- W1977126789 hasConceptScore W1977126789C142724271 @default.
- W1977126789 hasConceptScore W1977126789C167552308 @default.
- W1977126789 hasConceptScore W1977126789C2780723003 @default.
- W1977126789 hasConceptScore W1977126789C29730261 @default.
- W1977126789 hasConceptScore W1977126789C3020547009 @default.
- W1977126789 hasConceptScore W1977126789C53164099 @default.
- W1977126789 hasConceptScore W1977126789C71924100 @default.
- W1977126789 hasConceptScore W1977126789C98274493 @default.
- W1977126789 hasIssue "4" @default.
- W1977126789 hasLocation W19771267891 @default.
- W1977126789 hasOpenAccess W1977126789 @default.
- W1977126789 hasPrimaryLocation W19771267891 @default.
- W1977126789 hasRelatedWork W1848856669 @default.
- W1977126789 hasRelatedWork W18510784 @default.
- W1977126789 hasRelatedWork W1984264929 @default.
- W1977126789 hasRelatedWork W2017100795 @default.
- W1977126789 hasRelatedWork W2098329286 @default.
- W1977126789 hasRelatedWork W2127237301 @default.
- W1977126789 hasRelatedWork W2285749141 @default.
- W1977126789 hasRelatedWork W2460305965 @default.
- W1977126789 hasRelatedWork W2471865082 @default.
- W1977126789 hasRelatedWork W26119846 @default.
- W1977126789 hasRelatedWork W2913830744 @default.
- W1977126789 hasRelatedWork W2958568246 @default.
- W1977126789 hasRelatedWork W2994208923 @default.
- W1977126789 hasRelatedWork W2999822154 @default.
- W1977126789 hasRelatedWork W3117005264 @default.
- W1977126789 hasRelatedWork W3151597778 @default.
- W1977126789 hasRelatedWork W3208504782 @default.
- W1977126789 hasRelatedWork W1523417087 @default.
- W1977126789 hasRelatedWork W2189168568 @default.
- W1977126789 hasRelatedWork W2416486405 @default.
- W1977126789 hasVolume "2" @default.
- W1977126789 isParatext "false" @default.
- W1977126789 isRetracted "false" @default.
- W1977126789 magId "1977126789" @default.
- W1977126789 workType "article" @default.