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- W1977127588 abstract "Anti-apoptotic proteins, such as B-cell lymphoma (Bcl-2) protein, myeloid cell leukemia sequence 1 (Mcl-1) protein, are potential targets for cancer treatment. In the studies, a series of pyrrolidine derivatives were developed as potent Mcl-1 inhibitors. The preliminary biological studies suggested that most of target compounds exhibit good abilities for targeting Mcl-1 protein. Among them, compound 21 (Ki = 0.53 μM) exhibited equal inhibitory activities towards Mcl-1 protein compared to positive control gossypol (Ki = 0.39 μM). This compound also possessed good antiproliferative activities against MDA-MB-231 and PC-3 cancer cells." @default.
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- W1977127588 date "2010-06-01" @default.
- W1977127588 modified "2023-10-18" @default.
- W1977127588 title "Changes in the family of Bcl-2 proteins and oxidative stress markers in the right ventricle of autopsied hearts of patients who succummed with heart failure" @default.
- W1977127588 doi "https://doi.org/10.1016/j.clinbiochem.2010.04.012" @default.
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