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• W1977128178 abstract "Most extracellular glutamate in the brain is released by xCT, a glial antiporter that exports glutamate and imports cystine. The function of xCT, and extracellular glutamate in general, remains unclear. Several lines of evidence suggest that glutamate from xCT could act in a paracrine fashion to suppress glutamatergic synapse strength by triggering removal of postsynaptic glutamate receptors. To test this idea, we used whole-cell patch-clamp electrophysiology and immunohistochemistry to quantify receptor number and synapse function in xCT knock-out mouse hippocampal CA3-CA1 synapses. Consistent with the hypothesis that xCT suppresses glutamate receptor number and synapse strength, xCT knock-out synapses showed increased AMPA receptor abundance with concomitant large enhancements of spontaneous and evoked synaptic transmission. We saw no evidence for changes in GABA receptor abundance or the overall number of glutamatergic synapses. The xCT knock-out phenotype was replicated by incubating slices in the xCT inhibitor (S)-4-carboxyphenylglycine, and consistent with the idea that xCT works by regulating extracellular glutamate, the xCT knock-out phenotype could be reproduced in controls by incubating the slices in glutamate-free aCSF. We conclude that glutamate secreted via xCT suppresses glutamatergic synapse strength by triggering removal of postsynaptic AMPA receptors." @default.
• W1977128178 created "2016-06-24" @default.
• W1977128178 creator A5013485836 @default.
• W1977128178 creator A5029473826 @default.
• W1977128178 date "2014-11-26" @default.
• W1977128178 modified "2023-10-13" @default.
• W1977128178 title "Regulation of Hippocampal Synaptic Strength by Glial xCT" @default.
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• W1977128178 doi "https://doi.org/10.1523/jneurosci.1267-14.2014" @default.
• W1977128178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6608479" @default.
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