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- W1977130309 abstract "Much attention has been focused in recent years on two particular metabolites of arachidonic acid, prostacyclin (PGI,) and thromboxane A, (TXA,). The prostanoid PGI, is the main product of arachidonic acid in all arteries and veins so far tested. It is a potent vasodilator and the strongest endogeneous inhibitor of platelet aggregation yet discovered. This very labile substance with a half-life of 2-3 min, spontaneously decays to 6-keto-PGF,,. TXA,, mainly formed by platelets, has precisely the opposite properties; it is a powerful platelet-aggregant and vasoconstrictor. This unstable substance with a half-life of 30 s is metabolized to the stable but inactive thromboxane & (TX&) (for references see Vane, 1982). A number of diseases have now been related to an imbalance in the PGI,-TXA, relationship. In general it seems that, in diseases related with thrombosis, PGI, production is decreased or TXA, formation increased or both, whilst the opposite is found in some diseases associated with an increased bleeding tendency. The exact significance of PGI, in pregnancy certainly remains to be defined. Although it could play a modulatory role in contractions induced by other prostaglandins, its most important function seems to relate to the haemodynamic changes, characterizing normal pregnancy, and to a local defence mechanism against thrombus formation, both during pregnancy and delivery. Some of the contributions of the Leuven group to this field will be summarized." @default.
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- W1977130309 date "1984-12-01" @default.
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- W1977130309 title "Prostacyclin in pregnancy" @default.
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- W1977130309 doi "https://doi.org/10.1016/0028-2243(84)90052-2" @default.
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