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- W1977132241 abstract "Human life expectancy has increased over the past 50 years due to scientific and medical advances and higher food availability. However, overweight and obesity affect more than 50% of adults and 15% of infants and adolescents. There has also been a marked increase in the prevalence of metabolic syndrome in recent decades, which has been associated with a reduction in nocturnal pineal production of melatonin with aging and an increased risk of coronary diseases, type 2 diabetes mellitus (T2DM) and death. Melatonin is currently under intensive investigation in experimental animal models of diabetes, obesity and MS at pharmacological doses (between 5 and 20 mg kg(-1) body weight), demonstrating its capacity to ameliorate the total metabolic profile and its potential as an alternative to conventional drug therapies for the disorders associated with the MS, i.e. elevated systolic blood pressure, and impairment of glucose homeostasis, plasma lipid profile, inflammation, oxidative stress, and increased body weight. An especially significant finding is the induction by melatonin of white adipose tissue browning, which may be related to its effects against oxidative stress, uncoupling the mitochondrial bioenergetic process by enhancing the expression of uncoupled-protein-1 (UCP-1), which has been related to body weight reduction in experimental animals. Further research is required to improve knowledge of this mechanism. Clinical studies are needed with the administration of pharmacological melatonin doses, because the dose has ranged between 0.050 and 0.16 mg kg(-1) bw in most studies to date. Melatonin is a natural phytochemical, and it is also important to test its beneficial metabolic effects when consumed in functional foods." @default.
- W1977132241 created "2016-06-24" @default.
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- W1977132241 date "2014-08-19" @default.
- W1977132241 modified "2023-10-17" @default.
- W1977132241 title "Melatonin and metabolic regulation: a review" @default.
- W1977132241 cites W105688798 @default.
- W1977132241 cites W1516167591 @default.
- W1977132241 cites W1529592271 @default.
- W1977132241 cites W1531362368 @default.
- W1977132241 cites W1539401343 @default.
- W1977132241 cites W1572206043 @default.
- W1977132241 cites W1583010521 @default.
- W1977132241 cites W1583940256 @default.
- W1977132241 cites W1738645460 @default.
- W1977132241 cites W1780056943 @default.
- W1977132241 cites W1793372331 @default.
- W1977132241 cites W1799788806 @default.
- W1977132241 cites W1927827326 @default.
- W1977132241 cites W1962775416 @default.
- W1977132241 cites W1962964894 @default.
- W1977132241 cites W1965054947 @default.
- W1977132241 cites W1966122290 @default.
- W1977132241 cites W1966708423 @default.
- W1977132241 cites W1969638507 @default.
- W1977132241 cites W1970130937 @default.
- W1977132241 cites W1970163730 @default.
- W1977132241 cites W1971060562 @default.
- W1977132241 cites W1971498929 @default.
- W1977132241 cites W1975366890 @default.
- W1977132241 cites W1977201018 @default.
- W1977132241 cites W1979626105 @default.
- W1977132241 cites W1980018066 @default.
- W1977132241 cites W1981422933 @default.
- W1977132241 cites W1981495544 @default.
- W1977132241 cites W1982563006 @default.
- W1977132241 cites W1985945913 @default.
- W1977132241 cites W1986457253 @default.
- W1977132241 cites W1988010651 @default.
- W1977132241 cites W1988065082 @default.
- W1977132241 cites W1988269619 @default.
- W1977132241 cites W1988934115 @default.
- W1977132241 cites W1989279575 @default.
- W1977132241 cites W1990305302 @default.
- W1977132241 cites W1992768960 @default.
- W1977132241 cites W1993536180 @default.
- W1977132241 cites W1994957236 @default.
- W1977132241 cites W1996284070 @default.
- W1977132241 cites W1996904074 @default.
- W1977132241 cites W1997463511 @default.
- W1977132241 cites W1998984241 @default.
- W1977132241 cites W1999568358 @default.
- W1977132241 cites W2000054651 @default.
- W1977132241 cites W2001927233 @default.
- W1977132241 cites W2003063616 @default.
- W1977132241 cites W2003643676 @default.
- W1977132241 cites W2003832460 @default.
- W1977132241 cites W2004356308 @default.
- W1977132241 cites W2005444257 @default.
- W1977132241 cites W2011627634 @default.
- W1977132241 cites W2013233045 @default.
- W1977132241 cites W2014512635 @default.
- W1977132241 cites W2016773288 @default.
- W1977132241 cites W2017566496 @default.
- W1977132241 cites W2019253922 @default.
- W1977132241 cites W2019444825 @default.
- W1977132241 cites W2020795577 @default.
- W1977132241 cites W2020951058 @default.
- W1977132241 cites W2023700147 @default.
- W1977132241 cites W2025419894 @default.
- W1977132241 cites W2025517512 @default.
- W1977132241 cites W2026825032 @default.
- W1977132241 cites W2027788207 @default.
- W1977132241 cites W2027818818 @default.
- W1977132241 cites W2029535496 @default.
- W1977132241 cites W2030789651 @default.
- W1977132241 cites W2031509851 @default.
- W1977132241 cites W2032042625 @default.
- W1977132241 cites W2032998015 @default.
- W1977132241 cites W2033023583 @default.
- W1977132241 cites W2038316668 @default.
- W1977132241 cites W2039425156 @default.
- W1977132241 cites W2040127060 @default.
- W1977132241 cites W2040432975 @default.
- W1977132241 cites W2040783342 @default.
- W1977132241 cites W2042585865 @default.
- W1977132241 cites W2043134073 @default.
- W1977132241 cites W2044815141 @default.
- W1977132241 cites W2046005854 @default.
- W1977132241 cites W2046612545 @default.
- W1977132241 cites W2046918657 @default.
- W1977132241 cites W2047334165 @default.