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- W1977147543 abstract "Expression of receptors for the Fc part of IgA (FcαR) by T lymphocytes was recently shown to be up-regulated after activation by T cell mitogens in the absence of IgA. We describe a similar increase on activated human B lymphocytes. FcαR were determined by labelling with human secretory IgA (0.5 mg/ml) and flow cytometry analysis after staining with fluoresceinated goat anti-IgA or goat anti-secretory component F(ab')2 fragments. B-enriched cell suspensions were prepared from peripheral blood or tonsils and activated by Staphylococcus aureus Cowan I, anti-IgM antibodies or E. coli lipopolysaccharide. All three activators increased the percentage of FcαR positive cells although only the former induced significant DNA synthesis. Finally recombinant interleukin 1 (10 nM) and interleukin 2 (10 IU/ml) but not interleukin 4 (300 units/ml) nor low-molecular-weight B cell growth factor induced an increase of FcαR expression. The data show that FcαR can be up-regulated on human B cells in the absence of exposure to IgA." @default.
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- W1977147543 date "1988-10-01" @default.
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- W1977147543 title "Up-regulation of receptors for IgA on activated human B lymphocytes" @default.
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- W1977147543 doi "https://doi.org/10.1016/0165-2478(88)90135-6" @default.
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