Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977152509> ?p ?o ?g. }
- W1977152509 endingPage "1412" @default.
- W1977152509 startingPage "1403" @default.
- W1977152509 abstract "Abstract Because of its overexpression in a range of solid tumors, the EphA2 receptor is a validated target for cancer therapeutics. We recently described a new targeted delivery system based on specific EphA2‐targeting peptides conjugated with the chemotherapeutic agent paclitaxel. Here, we investigate the chemical determinants responsible for the stability and degradation of these agents in plasma. Introducing modifications in both the peptide and the linker between the peptide and paclitaxel resulted in drug conjugates that are both long‐lived in rat plasma and that markedly decrease tumor size in a prostate cancer xenograft model compared with paclitaxel alone treatment. These studies identify critical rate‐limiting degradation sites on the peptide–drug conjugates, enabling the design of agents with increased stability and efficacy. These results provide support for our central hypothesis that peptide–drug conjugates targeting EphA2 represent an innovative and potentially effective strategy to selectively deliver cytotoxic drugs to cancer cells." @default.
- W1977152509 created "2016-06-24" @default.
- W1977152509 creator A5006519364 @default.
- W1977152509 creator A5019715058 @default.
- W1977152509 creator A5022796313 @default.
- W1977152509 creator A5024866939 @default.
- W1977152509 creator A5025818509 @default.
- W1977152509 creator A5031490587 @default.
- W1977152509 creator A5039004886 @default.
- W1977152509 creator A5069934756 @default.
- W1977152509 creator A5070670275 @default.
- W1977152509 date "2014-03-26" @default.
- W1977152509 modified "2023-10-17" @default.
- W1977152509 title "Design, Synthesis and Bioevaluation of an EphA2 Receptor-Based Targeted Delivery System" @default.
- W1977152509 cites W1525792717 @default.
- W1977152509 cites W1536223993 @default.
- W1977152509 cites W1930222757 @default.
- W1977152509 cites W1964166386 @default.
- W1977152509 cites W1967720639 @default.
- W1977152509 cites W1992187858 @default.
- W1977152509 cites W1997670728 @default.
- W1977152509 cites W2000027123 @default.
- W1977152509 cites W2000981078 @default.
- W1977152509 cites W2005278976 @default.
- W1977152509 cites W2005611806 @default.
- W1977152509 cites W2007876005 @default.
- W1977152509 cites W2023826034 @default.
- W1977152509 cites W2025338468 @default.
- W1977152509 cites W2029487310 @default.
- W1977152509 cites W2029838406 @default.
- W1977152509 cites W2038385234 @default.
- W1977152509 cites W2040574920 @default.
- W1977152509 cites W2043481243 @default.
- W1977152509 cites W2044647958 @default.
- W1977152509 cites W2045707438 @default.
- W1977152509 cites W2047970549 @default.
- W1977152509 cites W2049089181 @default.
- W1977152509 cites W2049547244 @default.
- W1977152509 cites W2050204464 @default.
- W1977152509 cites W2051134921 @default.
- W1977152509 cites W2054253814 @default.
- W1977152509 cites W2054891903 @default.
- W1977152509 cites W2055923193 @default.
- W1977152509 cites W2059126737 @default.
- W1977152509 cites W2071946945 @default.
- W1977152509 cites W2074480887 @default.
- W1977152509 cites W2092606584 @default.
- W1977152509 cites W2092860331 @default.
- W1977152509 cites W2094161067 @default.
- W1977152509 cites W2094663537 @default.
- W1977152509 cites W2100588727 @default.
- W1977152509 cites W2102109968 @default.
- W1977152509 cites W2107019456 @default.
- W1977152509 cites W2115472066 @default.
- W1977152509 cites W2118444588 @default.
- W1977152509 cites W2123647020 @default.
- W1977152509 cites W2131884474 @default.
- W1977152509 cites W2134514535 @default.
- W1977152509 cites W2141480447 @default.
- W1977152509 cites W2151398050 @default.
- W1977152509 cites W2152055261 @default.
- W1977152509 cites W2156834504 @default.
- W1977152509 cites W2163326536 @default.
- W1977152509 cites W2168369189 @default.
- W1977152509 doi "https://doi.org/10.1002/cmdc.201400067" @default.
- W1977152509 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4082471" @default.
- W1977152509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24677792" @default.
- W1977152509 hasPublicationYear "2014" @default.
- W1977152509 type Work @default.
- W1977152509 sameAs 1977152509 @default.
- W1977152509 citedByCount "29" @default.
- W1977152509 countsByYear W19771525092015 @default.
- W1977152509 countsByYear W19771525092016 @default.
- W1977152509 countsByYear W19771525092017 @default.
- W1977152509 countsByYear W19771525092018 @default.
- W1977152509 countsByYear W19771525092019 @default.
- W1977152509 countsByYear W19771525092020 @default.
- W1977152509 countsByYear W19771525092021 @default.
- W1977152509 countsByYear W19771525092022 @default.
- W1977152509 countsByYear W19771525092023 @default.
- W1977152509 crossrefType "journal-article" @default.
- W1977152509 hasAuthorship W1977152509A5006519364 @default.
- W1977152509 hasAuthorship W1977152509A5019715058 @default.
- W1977152509 hasAuthorship W1977152509A5022796313 @default.
- W1977152509 hasAuthorship W1977152509A5024866939 @default.
- W1977152509 hasAuthorship W1977152509A5025818509 @default.
- W1977152509 hasAuthorship W1977152509A5031490587 @default.
- W1977152509 hasAuthorship W1977152509A5039004886 @default.
- W1977152509 hasAuthorship W1977152509A5069934756 @default.
- W1977152509 hasAuthorship W1977152509A5070670275 @default.
- W1977152509 hasBestOaLocation W19771525092 @default.
- W1977152509 hasConcept C101544691 @default.
- W1977152509 hasConcept C111919701 @default.
- W1977152509 hasConcept C121608353 @default.
- W1977152509 hasConcept C126322002 @default.
- W1977152509 hasConcept C126511603 @default.
- W1977152509 hasConcept C134306372 @default.
- W1977152509 hasConcept C150582083 @default.