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- W1977163319 abstract "Abstract 2′-Deoxy-2′-methylene-6-azauridine (5) and 2-deoxy-2-methylene-6-azacytidine (8) have been synthesized via a multi-step procedure from 6-azauridine. 2′-Deoxy-2′-methylene-5-azacytidine (14a) and 2′-deoxy-2′-methylene-3-deazaguanosine (19a) and their corresponding a-anomers (14b and 19b) have been synthesized by the transglycosylation of 3′,5′-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2′-deoxy-2′- methyleneuridine (12) with silylated 5-azacytosine and silylated N 2-palmitoyl-3-deazaguanine, respectively, in the presence of trimethylsilyl trifluoromethanesulfonate as the catalyst in anhydrous dichloroethane, followed by separation of the isomers and deprotection of the blocking groups. These compounds were tested for cytotoxicity against B16F10, L1210, and CCRF-CEM tumor cell lines and for antiviral activity against HIV-1, HSV-1, and HSV-2." @default.
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- W1977163319 date "1999-01-01" @default.
- W1977163319 modified "2023-09-24" @default.
- W1977163319 title "Synthesis of 2′-Methylene-Substituted 5-Azapyrimidine, 6-Azapyrimidine, and 3-Deazaguanine Nucleoside Analogues as Potential Antitumor/Antiviral Agents" @default.
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- W1977163319 doi "https://doi.org/10.1080/07328319908045594" @default.
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