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- W1977170150 endingPage "4140" @default.
- W1977170150 startingPage "4131" @default.
- W1977170150 abstract "The acquisition of oncogenic mutations and promotion of angiogenesis are key hallmarks of cancer. These features are often thought of as separate events in tumor progression and the two fields of research have frequently been considered as independent. However, as we highlight in this review, activated oncogenes and deregulated angiogenesis are tightly associated, as mutations in cancer cells can lead to perturbation of the pro- and anti-angiogenic balance thereby causing aberrant angiogenesis. We propose that normalization of the vascular network by targeting oncogenes in the tumor cells might lead to more efficient and sustained therapeutic effects compared to therapies targeting tumor vessels. We discuss how pharmacological inhibition of oncogenes in tumor cells restores a functional vasculature by bystander anti-angiogenic effect. As genetic alterations are tumor-specific, targeted therapy, which potentially blocks the angiogenic program activated by individual oncogenes may lead to personalized anti-angiogenic therapy." @default.
- W1977170150 created "2016-06-24" @default.
- W1977170150 creator A5064011158 @default.
- W1977170150 creator A5080620360 @default.
- W1977170150 date "2013-05-18" @default.
- W1977170150 modified "2023-10-09" @default.
- W1977170150 title "Oncogenes and angiogenesis: a way to personalize anti-angiogenic therapy?" @default.
- W1977170150 cites W1480357432 @default.
- W1977170150 cites W1508497000 @default.
- W1977170150 cites W1539571840 @default.
- W1977170150 cites W1573363574 @default.
- W1977170150 cites W1679229092 @default.
- W1977170150 cites W1967600348 @default.
- W1977170150 cites W1969191130 @default.
- W1977170150 cites W1969328947 @default.
- W1977170150 cites W1970918239 @default.
- W1977170150 cites W1971837077 @default.
- W1977170150 cites W1977999028 @default.
- W1977170150 cites W1978139448 @default.
- W1977170150 cites W1983763042 @default.
- W1977170150 cites W1983961550 @default.
- W1977170150 cites W1989223606 @default.
- W1977170150 cites W1989401206 @default.
- W1977170150 cites W1992177486 @default.
- W1977170150 cites W1993866602 @default.
- W1977170150 cites W1998573869 @default.
- W1977170150 cites W1999356404 @default.
- W1977170150 cites W1999966467 @default.
- W1977170150 cites W2000624133 @default.
- W1977170150 cites W2003992121 @default.
- W1977170150 cites W2006202974 @default.
- W1977170150 cites W2013312964 @default.
- W1977170150 cites W2014503004 @default.
- W1977170150 cites W2016024884 @default.
- W1977170150 cites W2016086822 @default.
- W1977170150 cites W2016569548 @default.
- W1977170150 cites W2017322644 @default.
- W1977170150 cites W2018016372 @default.
- W1977170150 cites W2019273955 @default.
- W1977170150 cites W2025036947 @default.
- W1977170150 cites W2029203122 @default.
- W1977170150 cites W2029470215 @default.
- W1977170150 cites W2030816211 @default.
- W1977170150 cites W2032220572 @default.
- W1977170150 cites W2032769992 @default.
- W1977170150 cites W2033791403 @default.
- W1977170150 cites W2034801324 @default.
- W1977170150 cites W2038422485 @default.
- W1977170150 cites W2043863730 @default.
- W1977170150 cites W2044905529 @default.
- W1977170150 cites W2051588629 @default.
- W1977170150 cites W2056408500 @default.
- W1977170150 cites W2058127641 @default.
- W1977170150 cites W2062594120 @default.
- W1977170150 cites W2062997257 @default.
- W1977170150 cites W2064412032 @default.
- W1977170150 cites W2067541859 @default.
- W1977170150 cites W2070572487 @default.
- W1977170150 cites W2070800535 @default.
- W1977170150 cites W2072554910 @default.
- W1977170150 cites W2077919252 @default.
- W1977170150 cites W2085153747 @default.
- W1977170150 cites W2090755907 @default.
- W1977170150 cites W2090785782 @default.
- W1977170150 cites W2099087398 @default.
- W1977170150 cites W2099088585 @default.
- W1977170150 cites W2101037339 @default.
- W1977170150 cites W2101144899 @default.
- W1977170150 cites W2101918466 @default.
- W1977170150 cites W2103027517 @default.
- W1977170150 cites W2103928688 @default.
- W1977170150 cites W2104300873 @default.
- W1977170150 cites W2105677187 @default.
- W1977170150 cites W2108733591 @default.
- W1977170150 cites W2110088809 @default.
- W1977170150 cites W2112703519 @default.
- W1977170150 cites W2115005218 @default.
- W1977170150 cites W2116177733 @default.
- W1977170150 cites W2116629325 @default.
- W1977170150 cites W2117474703 @default.
- W1977170150 cites W2117692326 @default.
- W1977170150 cites W2119793842 @default.
- W1977170150 cites W2120129511 @default.
- W1977170150 cites W2125703895 @default.
- W1977170150 cites W2125857654 @default.
- W1977170150 cites W2126275851 @default.
- W1977170150 cites W2127209890 @default.
- W1977170150 cites W2132318673 @default.
- W1977170150 cites W2133410449 @default.
- W1977170150 cites W2136596547 @default.
- W1977170150 cites W2139877124 @default.
- W1977170150 cites W2140088548 @default.
- W1977170150 cites W2140765540 @default.
- W1977170150 cites W2142906517 @default.
- W1977170150 cites W2144262617 @default.
- W1977170150 cites W2144930084 @default.
- W1977170150 cites W2145835533 @default.
- W1977170150 cites W2147535764 @default.