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• W1977175031 endingPage "548" @default.
• W1977175031 startingPage "539" @default.
• W1977175031 abstract "Amino acid (AA) deprivation in mammalian cells activates a collection of signaling cascades known as the AA response (AAR), which is characterized by transcriptional induction of stress-related genes, including FBJ murine osteosarcoma viral oncogene homolog (cFOS). The present study established that the signaling mechanism underlying the AA-dependent transcriptional regulation of the cFOS gene in HepG2 human hepatocellular carcinoma cells is independent of the classic GCN2-eIF2-ATF4 pathway. Instead, a RAS-RAF-MEK-ERK cascade mediates AAR signaling to the cFOS gene. Increased cFOS transcription is observed from 4-24 h after AAR-activation, exhibiting little or no overlap with the rapid and transient increase triggered by the well-known serum response. Furthermore, serum is not required for the AA-responsiveness of the cFOS gene and no phosphorylation of promoter-bound serum response factor (SRF) is observed. The ERK-phosphorylated transcription factor E-twenty six-like (p-ELK1) is increased in its association with the cFOS promoter after activation of the AAR. This research identified cFOS as a target of the AAR and further highlights the importance of AA-responsive MAPK signaling in HepG2 cells." @default.
• W1977175031 created "2016-06-24" @default.
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• W1977175031 date "2015-03-01" @default.
• W1977175031 modified "2023-09-22" @default.
• W1977175031 title "MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells" @default.
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• W1977175031 doi "https://doi.org/10.1016/j.bbamcr.2014.12.013" @default.
• W1977175031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4315773" @default.
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