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• W1977202387 endingPage "128" @default.
• W1977202387 startingPage "112" @default.
• W1977202387 abstract "Neuronal excitability can be regulated through modulation of voltage threshold (Vth). Previous studies suggested that this modulation could be mediated by modulation of transient sodium currents (I(T)) and/or persistent inward current (PIC). Modulation of I(T) and PIC through activation of protein kinase C (PKC) has previously been described as a mechanism controlling neuronal excitability. We investigated modulation of I(T) and PIC by PKC in neonatal rat spinal ventral neurons. In whole cell voltage clamp, activation of PKC by application of 1-oleoyl-2-acetyl-sn-glycerol (OAG, 10-30 microM) resulted in 1) a reduction of I(T) amplitude by 33% accompanied an increase in half-width and a decrease in the maximal rise and decay rates of the I(T); 2) a reduction of PIC amplitude by 49%, with a depolarization of PIC onset by 4.5 mV. Activation of PKC caused varied effects on Vth for eliciting I(T), with an unchanged Vth or depolarized Vth being the most common effects. In current-clamp recordings, PKC activation produced a small but significant depolarization (2.0 mV) of Vth for action potential generation with an increase in half-width and a decrease in amplitude and the maximal rise and decay rates of action potentials. Inclusion of PKCI19-36 (10-30 microM), a PKC inhibitor, in the recording pipette could block the OAG effects on I(T) and PIC. The ability of serotonin to hyperpolarize Vth was not altered by PKC activation or inhibition. This study demonstrates that activation of PKC decreases the excitability of spinal ventral neurons and that Vth can be modulated by multiple mechanisms." @default.
• W1977202387 created "2016-06-24" @default.
• W1977202387 creator A5006383292 @default.
• W1977202387 creator A5059205519 @default.
• W1977202387 creator A5060174174 @default.
• W1977202387 date "2009-01-01" @default.
• W1977202387 modified "2023-09-27" @default.
• W1977202387 title "Modulation of Transient and Persistent Inward Currents by Activation of Protein Kinase C in Spinal Ventral Neurons of the Neonatal Rat" @default.
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• W1977202387 doi "https://doi.org/10.1152/jn.01373.2007" @default.
• W1977202387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18945814" @default.
• W1977202387 hasPublicationYear "2009" @default.
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