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- W1977205447 abstract "Two phases are differentiated in botulinal intoxication: (1) a period of stimulation and (2) of respiratory depression. Experiments with picrotoxin point to reciprocal potentiation during the phase of botulinal stimulation and antagonism during the phase of depression.The botulinal toxin (type A) in these experiments was prepared and supplied by the National Institute of Health in Washington. Its potency was expressed in terms of an intravenous mouse MLD, one unit being 0.00005 cc, the smallest amount that would kill a 17 to 20 g mouse when injected intravenously.These experiments were performed on healthy stock rabbits ranging in weights from 1.45 to 1.85 kg.Injected into the marginal ear vein 10,000 U (0.5 cc) of the toxin caused death (100%) within 13 hours average time. Three mg of picrotoxin intravenously administered is surely convulsant and frequently lethal; 2 mg is usually convulsant but non-lethal; while 1 mg is never lethal, rarely convulsant but regularly hyper-stimulating to normal rabbits wi..." @default.
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- W1977205447 date "1939-03-01" @default.
- W1977205447 modified "2023-09-27" @default.
- W1977205447 title "Botulism and Picrotoxin" @default.
- W1977205447 doi "https://doi.org/10.3181/00379727-40-10428" @default.
- W1977205447 hasPublicationYear "1939" @default.
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