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- W1977208041 abstract "The present studies were conducted to determine whether [3H]quinuclidinyl benzilate binding in rat colonic membranes and/or carbachol-mediated stimulation of particulate guanylate cyclase were altered by changes in vitamin D status. EC50 values for the stimulation of colonic guanylate cyclase by carbachol were found to be significantly greater in vitamin D-deficient rats compared to their D-sufficient counterparts. Concomitantly, the density of receptors (Bmax) were significantly lower, and dissociation constants (Kd) were significantly higher in D-deficient colonic membranes. In vitamin D-repleted animals, moreover, all of these aforementioned alterations were at least partially corrected." @default.
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- W1977208041 date "1994-06-20" @default.
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- W1977208041 title "Vitamin D status modulates rat colonic M3muscarinic receptor characteristics and coupling to guanylate cyclase" @default.
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- W1977208041 doi "https://doi.org/10.1016/0014-5793(94)00498-6" @default.
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