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- W1977223721 abstract "Abstract Regio- and stereoselective 1,3-dipolar cycloadditions of C -(3-indolyl)- N -phenylnitrone ( 10 ) were carried out with different mono-substituted, disubstituted and cyclic dipolarophiles under mono-mode microwave irradiation to obtain substituted 3-(indol-3′-yl)- N -phenyl-isoxazolidines ( 16–22 ). Reactions of nitrone ( 10 ) with allenic esters under similar conditions afforded, via a domino process, bis-indole derivatives ( 23a – c ) along with compounds 24 and 25 . Similarly, reactions of C -(3-pyridyl)- N -phenylnitrone ( 26 ) with mono-substituted, disubstituted and cyclic dipolarophiles were carried out in refluxing dry toluene to obtain substituted 3-(3′-pyridyl)- N -phenylisoxazolidines ( 27–34 ). Some of the compounds ( 16f , 18b , 23a , 23c , 27c and 29f ) display significant cytotoxicity against a number of human cancer cell lines." @default.
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- W1977223721 date "2012-02-01" @default.
- W1977223721 modified "2023-09-29" @default.
- W1977223721 title "Synthesis and cytotoxic evaluation of substituted 3-(3′-indolyl-/3′-pyridyl)-isoxazolidines and bis-indoles" @default.
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- W1977223721 doi "https://doi.org/10.1016/j.apsb.2011.12.009" @default.
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