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- W1977230291 endingPage "e983862" @default.
- W1977230291 startingPage "e983862" @default.
- W1977230291 abstract "Rho-GTPases belong to the Ras superfamily and are crucial signal transducing proteins downstream of many receptors. In general, the Rho-GTPases function as molecular switches, cycling between inactive (GDP-bound) and active (GTP-bound) states. The activated GTP bound Rho-GTPases interact with a broad spectrum of effectors to regulate a plethora of biological pathways including cytoskeletal dynamics, motility, cytokinesis, cell growth, apoptosis, transcriptional activity and nuclear signaling. Recently, gene targeting in mice allowed the selective inactivation of different Rho-GTPases and has advanced our understanding of the physiological role of these proteins, particularly in the immune system. Particularly, these proteins are key signaling molecules in T lymphocytes, which are generated in the thymus and are major players in the immune system. The scope of this review is to discuss recent data obtained in Rho-GTPases deficient mice by focusing on the role-played by Rho-GTPases in T-lymphocyte development, migration, activation and differentiation." @default.
- W1977230291 created "2016-06-24" @default.
- W1977230291 creator A5022071699 @default.
- W1977230291 creator A5044947156 @default.
- W1977230291 creator A5055125868 @default.
- W1977230291 creator A5075934106 @default.
- W1977230291 date "2014-10-02" @default.
- W1977230291 modified "2023-09-30" @default.
- W1977230291 title "Rho-GTPases as key regulators of T lymphocyte biology" @default.
- W1977230291 cites W1233997596 @default.
- W1977230291 cites W1489763846 @default.
- W1977230291 cites W1491270159 @default.
- W1977230291 cites W1543561087 @default.
- W1977230291 cites W1565906667 @default.
- W1977230291 cites W1899300904 @default.
- W1977230291 cites W1927269833 @default.
- W1977230291 cites W1969632377 @default.
- W1977230291 cites W1970170695 @default.
- W1977230291 cites W1971286181 @default.
- W1977230291 cites W1974003730 @default.
- W1977230291 cites W1974595919 @default.
- W1977230291 cites W1977043587 @default.
- W1977230291 cites W1977593030 @default.
- W1977230291 cites W1978649277 @default.
- W1977230291 cites W1979657237 @default.
- W1977230291 cites W1979713589 @default.
- W1977230291 cites W1984491329 @default.
- W1977230291 cites W1986013003 @default.
- W1977230291 cites W1986126368 @default.
- W1977230291 cites W1986457181 @default.
- W1977230291 cites W1987295549 @default.
- W1977230291 cites W1988650452 @default.
- W1977230291 cites W1989550450 @default.
- W1977230291 cites W1993932758 @default.
- W1977230291 cites W2002726823 @default.
- W1977230291 cites W2004762438 @default.
- W1977230291 cites W2008063123 @default.
- W1977230291 cites W2012300995 @default.
- W1977230291 cites W2013592169 @default.
- W1977230291 cites W2019731805 @default.
- W1977230291 cites W2020603414 @default.
- W1977230291 cites W2020821589 @default.
- W1977230291 cites W2024826879 @default.
- W1977230291 cites W2034980526 @default.
- W1977230291 cites W2042130821 @default.
- W1977230291 cites W2042626190 @default.
- W1977230291 cites W2044356299 @default.
- W1977230291 cites W2045671766 @default.
- W1977230291 cites W2046477120 @default.
- W1977230291 cites W2046966521 @default.
- W1977230291 cites W2048674030 @default.
- W1977230291 cites W2049897598 @default.
- W1977230291 cites W2058600007 @default.
- W1977230291 cites W2061482218 @default.
- W1977230291 cites W2066872359 @default.
- W1977230291 cites W2071199281 @default.
- W1977230291 cites W2071549331 @default.
- W1977230291 cites W2072853625 @default.
- W1977230291 cites W2072984471 @default.
- W1977230291 cites W2074249987 @default.
- W1977230291 cites W2077487647 @default.
- W1977230291 cites W2077792958 @default.
- W1977230291 cites W2079749432 @default.
- W1977230291 cites W2080304943 @default.
- W1977230291 cites W2081100902 @default.
- W1977230291 cites W2082427792 @default.
- W1977230291 cites W2086595653 @default.
- W1977230291 cites W2087025778 @default.
- W1977230291 cites W2087698341 @default.
- W1977230291 cites W2089633707 @default.
- W1977230291 cites W2092919466 @default.
- W1977230291 cites W2093832003 @default.
- W1977230291 cites W2095562167 @default.
- W1977230291 cites W2096234619 @default.
- W1977230291 cites W2096791952 @default.
- W1977230291 cites W2097463362 @default.
- W1977230291 cites W2100699905 @default.
- W1977230291 cites W2101852814 @default.
- W1977230291 cites W2102312968 @default.
- W1977230291 cites W2106881778 @default.
- W1977230291 cites W2107724577 @default.
- W1977230291 cites W2108715505 @default.
- W1977230291 cites W2117504973 @default.
- W1977230291 cites W2120909571 @default.
- W1977230291 cites W2124116262 @default.
- W1977230291 cites W2130486201 @default.
- W1977230291 cites W2130542798 @default.
- W1977230291 cites W2132928628 @default.
- W1977230291 cites W2135743634 @default.
- W1977230291 cites W2146473598 @default.
- W1977230291 cites W2146689306 @default.
- W1977230291 cites W2147717055 @default.
- W1977230291 cites W2148562724 @default.
- W1977230291 cites W2156648441 @default.
- W1977230291 cites W2156901046 @default.
- W1977230291 cites W2158510222 @default.
- W1977230291 cites W2159683137 @default.
- W1977230291 cites W2160996325 @default.