FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977231617> ?p ?o ?g. }

• W1977231617 endingPage "272" @default.
• W1977231617 startingPage "264" @default.
• W1977231617 abstract "Abstract Recently, a new system of astrocyte–neurone glutamatergic signalling has been identified. It is started in astrocytes by ectocellular, CD38‐catalysed conversion of NAD + to the calcium mobilizer cyclic ADP‐ribose (cADPR). This is then pumped by CD38 itself into the cytosol where the resulting free intracellular Ca 2+ concentration [Ca 2+ ] i transients elicit an increased release of glutamate, which can induce an enhanced Ca 2+ response in neighbouring neurones. Here, we demonstrate that co‐culture of either cortical or hippocampal astrocytes with neurones results in a significant overexpression of astrocyte CD38 both on the plasma membrane and intracellularly. The causal role of neurone‐released glutamate in inducing overexpression of astrocyte CD38 is demonstrated by two observations: first, in the absence of neurones, induction of CD38 in pure astrocyte cultures can be obtained with glutamate and second, it can be prevented in co‐cultures by glutamate receptor antagonists. The neuronal glutamate‐mediated effect of neurones on astrocyte CD38 expression is paralleled by increased intracellular cADPR and [Ca 2+ ] i levels, both findings indicating functionality of overexpressed CD38. These results reveal a new neurone‐to‐astrocyte glutamatergic signalling based on the CD38/cADPR system, which affects the [Ca 2+ ] i in both cell types, adding further complexity to the bi‐directional patterns of communication between astrocytes and neurones." @default.
• W1977231617 created "2016-06-24" @default.
• W1977231617 creator A5001942139 @default.
• W1977231617 creator A5015065739 @default.
• W1977231617 creator A5024982893 @default.
• W1977231617 creator A5048757910 @default.
• W1977231617 creator A5067496909 @default.
• W1977231617 creator A5071067909 @default.
• W1977231617 creator A5075935583 @default.
• W1977231617 date "2004-03-10" @default.
• W1977231617 modified "2023-10-18" @default.
• W1977231617 title "Glutamate-mediated overexpression of CD38 in astrocytes cultured with neurones" @default.
• W1977231617 cites W123308499 @default.
• W1977231617 cites W144057731 @default.
• W1977231617 cites W1516426911 @default.
• W1977231617 cites W1517749679 @default.
• W1977231617 cites W1529341137 @default.
• W1977231617 cites W1541085684 @default.
• W1977231617 cites W1571034236 @default.
• W1977231617 cites W1580586916 @default.
• W1977231617 cites W1882376829 @default.
• W1977231617 cites W1954747488 @default.
• W1977231617 cites W1959465208 @default.
• W1977231617 cites W1970549117 @default.
• W1977231617 cites W1987700551 @default.
• W1977231617 cites W1988000108 @default.
• W1977231617 cites W1992091715 @default.
• W1977231617 cites W1992807239 @default.
• W1977231617 cites W1998778584 @default.
• W1977231617 cites W2006980729 @default.
• W1977231617 cites W2010658521 @default.
• W1977231617 cites W2011543303 @default.
• W1977231617 cites W2012174792 @default.
• W1977231617 cites W2015820951 @default.
• W1977231617 cites W2018443770 @default.
• W1977231617 cites W2034565593 @default.
• W1977231617 cites W2047331722 @default.
• W1977231617 cites W2050452462 @default.
• W1977231617 cites W2059354304 @default.
• W1977231617 cites W2068400560 @default.
• W1977231617 cites W2070764341 @default.
• W1977231617 cites W2071680628 @default.
• W1977231617 cites W2075061896 @default.
• W1977231617 cites W2082186085 @default.
• W1977231617 cites W2094870161 @default.
• W1977231617 cites W2101108802 @default.
• W1977231617 cites W2111547035 @default.
• W1977231617 cites W2113995373 @default.
• W1977231617 cites W2117576534 @default.
• W1977231617 cites W2118522143 @default.
• W1977231617 cites W2139374120 @default.
• W1977231617 cites W2140477475 @default.
• W1977231617 cites W2140924908 @default.
• W1977231617 cites W2141621434 @default.
• W1977231617 cites W2153549293 @default.
• W1977231617 cites W2155989580 @default.
• W1977231617 cites W2171863507 @default.
• W1977231617 cites W2184516036 @default.
• W1977231617 cites W2285808960 @default.
• W1977231617 cites W4231725743 @default.
• W1977231617 cites W4293247451 @default.
• W1977231617 cites W4294412675 @default.
• W1977231617 cites W4294415022 @default.
• W1977231617 cites W4312615442 @default.
• W1977231617 cites W4323966320 @default.
• W1977231617 cites W638178902 @default.
• W1977231617 doi "https://doi.org/10.1111/j.1471-4159.2003.02326.x" @default.
• W1977231617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15030411" @default.
• W1977231617 hasPublicationYear "2004" @default.
• W1977231617 type Work @default.
• W1977231617 sameAs 1977231617 @default.
• W1977231617 citedByCount "47" @default.
• W1977231617 countsByYear W19772316172012 @default.
• W1977231617 countsByYear W19772316172013 @default.
• W1977231617 countsByYear W19772316172014 @default.
• W1977231617 countsByYear W19772316172015 @default.
• W1977231617 countsByYear W19772316172016 @default.
• W1977231617 countsByYear W19772316172017 @default.
• W1977231617 countsByYear W19772316172019 @default.
• W1977231617 countsByYear W19772316172020 @default.
• W1977231617 countsByYear W19772316172021 @default.
• W1977231617 countsByYear W19772316172022 @default.
• W1977231617 countsByYear W19772316172023 @default.
• W1977231617 crossrefType "journal-article" @default.
• W1977231617 hasAuthorship W1977231617A5001942139 @default.
• W1977231617 hasAuthorship W1977231617A5015065739 @default.
• W1977231617 hasAuthorship W1977231617A5024982893 @default.
• W1977231617 hasAuthorship W1977231617A5048757910 @default.
• W1977231617 hasAuthorship W1977231617A5067496909 @default.
• W1977231617 hasAuthorship W1977231617A5071067909 @default.
• W1977231617 hasAuthorship W1977231617A5075935583 @default.
• W1977231617 hasConcept C12554922 @default.
• W1977231617 hasConcept C169760540 @default.
• W1977231617 hasConcept C170493617 @default.
• W1977231617 hasConcept C185592680 @default.
• W1977231617 hasConcept C2777542381 @default.
• W1977231617 hasConcept C2780648746 @default.
• W1977231617 hasConcept C529278444 @default.

• next