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- W1977232011 abstract "The serine esterase inhibitor diisopropyl fluorophosphate (DFP) has been shown to inhibit IgE-dependent histamine release. Recently, it has been demonstrated that lower concentrations of DFP enhanced IgE-dependent histamine release and inhibited desensitization. This manuscript describes the ability of another esterase inhibitor, pinacolyl methylphosphorofluoridate (soman), to directly cause release of histamine from human leukocytes (basophils) by a process that is IgE-independent. This release process requires calcium and is also temperature-dependent but occurs over a longer period of time than IgE-dependent release. These data suggest that there is a serine esterase which controls histamine release, and inhibition of this esterase causes histamine release." @default.
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- W1977232011 date "1985-01-01" @default.
- W1977232011 modified "2023-09-23" @default.
- W1977232011 title "Histamine release by esterase inhibitors. The regulation of histamine release from human leukocytes of allergic and non-allergic individuals by the serine esterase inhibitors diisopropyl fluorophosphate and pinacolyl methylphosphorofluoridate." @default.
- W1977232011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2409020" @default.
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