FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977235697> ?p ?o ?g. }

• W1977235697 endingPage "33" @default.
• W1977235697 startingPage "26" @default.
• W1977235697 abstract "Background & Aims: The human multidrug resistance 1 (MDR1) gene product P-glycoprotein is highly expressed in intestinal epithelial cells, where it constitutes a barrier against xenobiotics. The finding that mdr1a knockout mice develop a form of colitis that is similar to ulcerative colitis, which can be prevented by antibiotics, indicates a barrier function for P-glycoprotein against the invasion of bacteria or toxins. Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis. Methods: Allele frequencies and genotype distributions of the C3435T single nucleotide polymorphism were investigated in 149 patients with ulcerative colitis, 126 patients with Crohn's disease, and sex-matched healthy controls. Results: Significantly increased frequencies of the 3435T allele and the 3435TT genotype were observed in patients with ulcerative colitis compared with controls (3435T: P = 0.049; odds ratio, 1.4; 95% confidence interval, 1.02–1.94; 3435TT: P = 0.045; odds ratio, 2.03; 95% confidence interval, 1.04–3.95). In contrast, frequencies of the T allele and the TT genotype were the same in patients with Crohn's disease as in controls (P = 0.66 and P = 0.59, respectively). In comparison to 998 non–sex-matched controls, the effect for the TT genotype in ulcerative colitis patients was more pronounced (P = 0.0055; odds ratio, 2.1). Conclusions: The higher frequency of the 3435TT genotype in patients with ulcerative colitis corroborates the findings from the mdr1a knockout mice. The results support the notion that P-glycoprotein plays a major role in the defense against intestinal bacteria or toxins. Impairment of barrier function in 3435TT subjects could render this genotype more susceptible to the development of ulcerative colitis.GASTROENTEROLOGY 2003;124:26-33" @default.
• W1977235697 created "2016-06-24" @default.
• W1977235697 creator A5001414279 @default.
• W1977235697 creator A5012351880 @default.
• W1977235697 creator A5023657124 @default.
• W1977235697 creator A5027515633 @default.
• W1977235697 creator A5029630686 @default.
• W1977235697 creator A5030993480 @default.
• W1977235697 creator A5044688765 @default.
• W1977235697 creator A5055990904 @default.
• W1977235697 creator A5057183308 @default.
• W1977235697 creator A5058723840 @default.
• W1977235697 creator A5059195101 @default.
• W1977235697 creator A5061672123 @default.
• W1977235697 creator A5065579354 @default.
• W1977235697 creator A5066057635 @default.
• W1977235697 creator A5070574042 @default.
• W1977235697 creator A5079998509 @default.
• W1977235697 date "2003-01-01" @default.
• W1977235697 modified "2023-10-11" @default.
• W1977235697 title "Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis" @default.
• W1977235697 cites W123422070 @default.
• W1977235697 cites W159720762 @default.
• W1977235697 cites W1642457845 @default.
• W1977235697 cites W1647483410 @default.
• W1977235697 cites W1670573097 @default.
• W1977235697 cites W1936114432 @default.
• W1977235697 cites W1964470226 @default.
• W1977235697 cites W1966912799 @default.
• W1977235697 cites W1968067289 @default.
• W1977235697 cites W1969767037 @default.
• W1977235697 cites W1972856183 @default.
• W1977235697 cites W1975261946 @default.
• W1977235697 cites W1982105713 @default.
• W1977235697 cites W2006240760 @default.
• W1977235697 cites W2014468456 @default.
• W1977235697 cites W2017411996 @default.
• W1977235697 cites W2022470615 @default.
• W1977235697 cites W2049520769 @default.
• W1977235697 cites W2052330087 @default.
• W1977235697 cites W2054458932 @default.
• W1977235697 cites W2057755081 @default.
• W1977235697 cites W2064027072 @default.
• W1977235697 cites W2065637841 @default.
• W1977235697 cites W2066919313 @default.
• W1977235697 cites W2067668617 @default.
• W1977235697 cites W2068865770 @default.
• W1977235697 cites W2077925418 @default.
• W1977235697 cites W2098142549 @default.
• W1977235697 cites W2098938825 @default.
• W1977235697 cites W2110886272 @default.
• W1977235697 cites W2117944128 @default.
• W1977235697 cites W2117974617 @default.
• W1977235697 cites W2118342649 @default.
• W1977235697 cites W2132548433 @default.
• W1977235697 cites W2132932170 @default.
• W1977235697 cites W2133936908 @default.
• W1977235697 cites W2136652614 @default.
• W1977235697 cites W2146906769 @default.
• W1977235697 cites W2152567941 @default.
• W1977235697 cites W2171279314 @default.
• W1977235697 cites W2404854108 @default.
• W1977235697 cites W32794514 @default.
• W1977235697 cites W4211000517 @default.
• W1977235697 doi "https://doi.org/10.1053/gast.2003.50010" @default.
• W1977235697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12512026" @default.
• W1977235697 hasPublicationYear "2003" @default.
• W1977235697 type Work @default.
• W1977235697 sameAs 1977235697 @default.
• W1977235697 citedByCount "304" @default.
• W1977235697 countsByYear W19772356972012 @default.
• W1977235697 countsByYear W19772356972013 @default.
• W1977235697 countsByYear W19772356972014 @default.
• W1977235697 countsByYear W19772356972015 @default.
• W1977235697 countsByYear W19772356972016 @default.
• W1977235697 countsByYear W19772356972017 @default.
• W1977235697 countsByYear W19772356972018 @default.
• W1977235697 countsByYear W19772356972019 @default.
• W1977235697 countsByYear W19772356972021 @default.
• W1977235697 countsByYear W19772356972022 @default.
• W1977235697 crossrefType "journal-article" @default.
• W1977235697 hasAuthorship W1977235697A5001414279 @default.
• W1977235697 hasAuthorship W1977235697A5012351880 @default.
• W1977235697 hasAuthorship W1977235697A5023657124 @default.
• W1977235697 hasAuthorship W1977235697A5027515633 @default.
• W1977235697 hasAuthorship W1977235697A5029630686 @default.
• W1977235697 hasAuthorship W1977235697A5030993480 @default.
• W1977235697 hasAuthorship W1977235697A5044688765 @default.
• W1977235697 hasAuthorship W1977235697A5055990904 @default.
• W1977235697 hasAuthorship W1977235697A5057183308 @default.
• W1977235697 hasAuthorship W1977235697A5058723840 @default.
• W1977235697 hasAuthorship W1977235697A5059195101 @default.
• W1977235697 hasAuthorship W1977235697A5061672123 @default.
• W1977235697 hasAuthorship W1977235697A5065579354 @default.
• W1977235697 hasAuthorship W1977235697A5066057635 @default.
• W1977235697 hasAuthorship W1977235697A5070574042 @default.
• W1977235697 hasAuthorship W1977235697A5079998509 @default.
• W1977235697 hasBestOaLocation W19772356971 @default.

• next