FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977236445> ?p ?o ?g. }

• W1977236445 endingPage "1126" @default.
• W1977236445 startingPage "1115" @default.
• W1977236445 abstract "The activity of the polyoma virus (PyV) origin of DNA replication was used as a sensitive assay for enhancer function in one- and two-cell mouse embryos by injecting embryos with plasmid DNA containing different PyV ori configurations, allowing them to continue development in vitro, and then measuring plasmid DNA replication. Replication always required the PyV origin 'core' sequence in cis and PyV large tumor antigen (T-Ag) in trans. In developing two-cell embryos, DNA replication also required an enhancer in cis. Two copies of part of PyV enhancer 3 (beta element) was sevenfold better than one copy, and enhancer 3 was better than enhancer 1 + 2 (alpha element). Competition between ori configurations suggested that enhancers bound specific proteins required for replication and transcription. In contrast, DNA injected into one-cell embryos did not need an enhancer for replication, and no competition for replication factors was observed between different ori configurations. In fact, ori core replicated about ninefold better in one-cell embryos than the complete origin did in developing two-cell embryos. Therefore, core contains all the cis-acting information necessary to initiate DNA replication. Because one-cell embryos that replicated injected DNA retained their pronuclei and remained one-cell embryos, enhancers are not needed in mammalian development until a diploid nucleus is formed." @default.
• W1977236445 created "2016-06-24" @default.
• W1977236445 creator A5033445671 @default.
• W1977236445 creator A5045461836 @default.
• W1977236445 creator A5074244487 @default.
• W1977236445 date "1988-09-01" @default.
• W1977236445 modified "2023-10-18" @default.
• W1977236445 title "The need for enhancers is acquired upon formation of a diploid nucleus during early mouse development." @default.
• W1977236445 cites W150805145 @default.
• W1977236445 cites W1561156464 @default.
• W1977236445 cites W1756042051 @default.
• W1977236445 cites W1766942009 @default.
• W1977236445 cites W1836619428 @default.
• W1977236445 cites W1917506099 @default.
• W1977236445 cites W1966717118 @default.
• W1977236445 cites W1971745506 @default.
• W1977236445 cites W1976942424 @default.
• W1977236445 cites W1979965541 @default.
• W1977236445 cites W1986291674 @default.
• W1977236445 cites W1998956033 @default.
• W1977236445 cites W1999939543 @default.
• W1977236445 cites W2005309070 @default.
• W1977236445 cites W2009230618 @default.
• W1977236445 cites W2014231001 @default.
• W1977236445 cites W2024219283 @default.
• W1977236445 cites W2027813738 @default.
• W1977236445 cites W2028656889 @default.
• W1977236445 cites W2037412722 @default.
• W1977236445 cites W2039294005 @default.
• W1977236445 cites W2041527402 @default.
• W1977236445 cites W2045583364 @default.
• W1977236445 cites W2063412487 @default.
• W1977236445 cites W2067036274 @default.
• W1977236445 cites W2069757711 @default.
• W1977236445 cites W2074565496 @default.
• W1977236445 cites W2080567269 @default.
• W1977236445 cites W2088622701 @default.
• W1977236445 cites W2089647779 @default.
• W1977236445 cites W2096659740 @default.
• W1977236445 cites W2097145517 @default.
• W1977236445 cites W2103431676 @default.
• W1977236445 cites W2129381471 @default.
• W1977236445 cites W2136347509 @default.
• W1977236445 cites W2165148733 @default.
• W1977236445 cites W2493816992 @default.
• W1977236445 cites W2495512328 @default.
• W1977236445 cites W2499414238 @default.
• W1977236445 cites W260224868 @default.
• W1977236445 doi "https://doi.org/10.1101/gad.2.9.1115" @default.
• W1977236445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2847960" @default.
• W1977236445 hasPublicationYear "1988" @default.
• W1977236445 type Work @default.
• W1977236445 sameAs 1977236445 @default.
• W1977236445 citedByCount "51" @default.
• W1977236445 countsByYear W19772364452016 @default.
• W1977236445 crossrefType "journal-article" @default.
• W1977236445 hasAuthorship W1977236445A5033445671 @default.
• W1977236445 hasAuthorship W1977236445A5045461836 @default.
• W1977236445 hasAuthorship W1977236445A5074244487 @default.
• W1977236445 hasBestOaLocation W19772364451 @default.
• W1977236445 hasConcept C104317684 @default.
• W1977236445 hasConcept C104690221 @default.
• W1977236445 hasConcept C111936080 @default.
• W1977236445 hasConcept C153911025 @default.
• W1977236445 hasConcept C175193931 @default.
• W1977236445 hasConcept C188036394 @default.
• W1977236445 hasConcept C196843134 @default.
• W1977236445 hasConcept C21784809 @default.
• W1977236445 hasConcept C54355233 @default.
• W1977236445 hasConcept C552990157 @default.
• W1977236445 hasConcept C73573662 @default.
• W1977236445 hasConcept C86339819 @default.
• W1977236445 hasConcept C86803240 @default.
• W1977236445 hasConcept C95444343 @default.
• W1977236445 hasConceptScore W1977236445C104317684 @default.
• W1977236445 hasConceptScore W1977236445C104690221 @default.
• W1977236445 hasConceptScore W1977236445C111936080 @default.
• W1977236445 hasConceptScore W1977236445C153911025 @default.
• W1977236445 hasConceptScore W1977236445C175193931 @default.
• W1977236445 hasConceptScore W1977236445C188036394 @default.
• W1977236445 hasConceptScore W1977236445C196843134 @default.
• W1977236445 hasConceptScore W1977236445C21784809 @default.
• W1977236445 hasConceptScore W1977236445C54355233 @default.
• W1977236445 hasConceptScore W1977236445C552990157 @default.
• W1977236445 hasConceptScore W1977236445C73573662 @default.
• W1977236445 hasConceptScore W1977236445C86339819 @default.
• W1977236445 hasConceptScore W1977236445C86803240 @default.
• W1977236445 hasConceptScore W1977236445C95444343 @default.
• W1977236445 hasIssue "9" @default.
• W1977236445 hasLocation W19772364451 @default.
• W1977236445 hasLocation W19772364452 @default.
• W1977236445 hasOpenAccess W1977236445 @default.
• W1977236445 hasPrimaryLocation W19772364451 @default.
• W1977236445 hasRelatedWork W148331623 @default.
• W1977236445 hasRelatedWork W1995806503 @default.
• W1977236445 hasRelatedWork W2020916241 @default.
• W1977236445 hasRelatedWork W2038164592 @default.
• W1977236445 hasRelatedWork W2610686479 @default.

• next