FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977247124> ?p ?o ?g. }

• W1977247124 abstract "The reduction of blood pressure alone does not eliminate the increased risk of arterial hypertension. Whilst concomitant metabolic risk factors have been shown to be responsible, the available pharmacotherapy has differential effects on these metabolic risk factors. For example, diuretics and betablockers worsen glucose metabolism, hence the starting point of the current subanalysis of the CHILI (Candesartan in patients with HIgher cardiovascuLar rIsk) study was the assumption that an angiotensin receptor blocker may counterbalance the metabolic effects of a low dose diuretic in patients with several metabolic risk factors.The present study was performed as a non-interventional observational study in Germany. Patients with previously uncontrolled hypertension with at least one further risk factor in which physicians deemed a treatment with 16 mg Candesartan/12.5 mg HCTZ to be necessary were included. The risk factors were calculated in patient subgroups with diabetes, the metabolic syndrome (MetSyn) and neither condition (control). The risk of cardiovascular mortality within the next 10 years was calculated using the SCORE algorithm of the ESC.Between August 2006 and February 2007 a total of 3,787 patients were included into the non-interventional trial. Patients were 62.2 +/- 11.3 years old, 48.1% were female, 97.5% had at least one additional risk factor. Blood pressure was reduced by -27.2/-13.4 mmHg with only minor non significant variations between patient groups. Waist circumference was reduced (P < 0.0001) and HDL-C elevated (P < 0.05) in every subgroup except the control subgroup. Fasting blood glucose was reduced by -5.6 +/- 21.6% (P < 0.0001 vs. baseline and vs. control) as well as triglycerides (-4.9 +/- 29.4%; P < 0.0001 vs. baseline and vs. control). The SCORE value was reduced substantially (-8.7, -3.2 and -2.7% in patients with diabetes, the metabolic syndrome or neither).The present study demonstrates that a 16 mg candesartan/12.5 mg HCTZ based treatment results in a pronounced blood pressure reduction and was associated with a favourable change in metabolic risk factors such as HDL cholesterol, triglycerides and blood glucose. These data indicate that metabolic effects observed in clinical trials like ALPINE, SCOPE or CHARM can also be observed in an unselected patient population in primary care." @default.
• W1977247124 created "2016-06-24" @default.
• W1977247124 creator A5036896843 @default.
• W1977247124 creator A5072081403 @default.
• W1977247124 creator A5078953106 @default.
• W1977247124 date "2008-11-10" @default.
• W1977247124 modified "2023-09-27" @default.
• W1977247124 title "Metabolic effects of an AT1-receptor blockade combined with HCTZ in cardiac risk patients: a non interventional study in primary care" @default.
• W1977247124 cites W1970475964 @default.
• W1977247124 cites W1976363273 @default.
• W1977247124 cites W1979030376 @default.
• W1977247124 cites W1988334706 @default.
• W1977247124 cites W2009853774 @default.
• W1977247124 cites W2012719211 @default.
• W1977247124 cites W2020498330 @default.
• W1977247124 cites W2048189779 @default.
• W1977247124 cites W2048748448 @default.
• W1977247124 cites W2090024638 @default.
• W1977247124 cites W2091247143 @default.
• W1977247124 cites W2092366048 @default.
• W1977247124 cites W2095637793 @default.
• W1977247124 cites W2107165713 @default.
• W1977247124 cites W2118569858 @default.
• W1977247124 cites W2121490027 @default.
• W1977247124 cites W2123289485 @default.
• W1977247124 cites W2141190970 @default.
• W1977247124 cites W2141659719 @default.
• W1977247124 cites W2144335239 @default.
• W1977247124 cites W2153769155 @default.
• W1977247124 cites W2154798443 @default.
• W1977247124 cites W2159854507 @default.
• W1977247124 cites W2160547085 @default.
• W1977247124 cites W2303651371 @default.
• W1977247124 cites W2319983832 @default.
• W1977247124 cites W4254209755 @default.
• W1977247124 cites W4254784503 @default.
• W1977247124 cites W75245760 @default.
• W1977247124 doi "https://doi.org/10.1186/1471-2261-8-30" @default.
• W1977247124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2588554" @default.
• W1977247124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19000308" @default.
• W1977247124 hasPublicationYear "2008" @default.
• W1977247124 type Work @default.
• W1977247124 sameAs 1977247124 @default.
• W1977247124 citedByCount "8" @default.
• W1977247124 countsByYear W19772471242012 @default.
• W1977247124 countsByYear W19772471242013 @default.
• W1977247124 countsByYear W19772471242014 @default.
• W1977247124 crossrefType "journal-article" @default.
• W1977247124 hasAuthorship W1977247124A5036896843 @default.
• W1977247124 hasAuthorship W1977247124A5072081403 @default.
• W1977247124 hasAuthorship W1977247124A5078953106 @default.
• W1977247124 hasBestOaLocation W19772471241 @default.
• W1977247124 hasConcept C126322002 @default.
• W1977247124 hasConcept C134018914 @default.
• W1977247124 hasConcept C164705383 @default.
• W1977247124 hasConcept C2780036600 @default.
• W1977247124 hasConcept C2780361556 @default.
• W1977247124 hasConcept C2780578515 @default.
• W1977247124 hasConcept C2908929049 @default.
• W1977247124 hasConcept C50440223 @default.
• W1977247124 hasConcept C555293320 @default.
• W1977247124 hasConcept C71924100 @default.
• W1977247124 hasConcept C84393581 @default.
• W1977247124 hasConceptScore W1977247124C126322002 @default.
• W1977247124 hasConceptScore W1977247124C134018914 @default.
• W1977247124 hasConceptScore W1977247124C164705383 @default.
• W1977247124 hasConceptScore W1977247124C2780036600 @default.
• W1977247124 hasConceptScore W1977247124C2780361556 @default.
• W1977247124 hasConceptScore W1977247124C2780578515 @default.
• W1977247124 hasConceptScore W1977247124C2908929049 @default.
• W1977247124 hasConceptScore W1977247124C50440223 @default.
• W1977247124 hasConceptScore W1977247124C555293320 @default.
• W1977247124 hasConceptScore W1977247124C71924100 @default.
• W1977247124 hasConceptScore W1977247124C84393581 @default.
• W1977247124 hasIssue "1" @default.
• W1977247124 hasLocation W19772471241 @default.
• W1977247124 hasLocation W19772471242 @default.
• W1977247124 hasLocation W19772471243 @default.
• W1977247124 hasLocation W19772471244 @default.
• W1977247124 hasOpenAccess W1977247124 @default.
• W1977247124 hasPrimaryLocation W19772471241 @default.
• W1977247124 hasRelatedWork W1966234050 @default.
• W1977247124 hasRelatedWork W1978722589 @default.
• W1977247124 hasRelatedWork W2019792346 @default.
• W1977247124 hasRelatedWork W2138029694 @default.
• W1977247124 hasRelatedWork W2149062689 @default.
• W1977247124 hasRelatedWork W2161644487 @default.
• W1977247124 hasRelatedWork W2171089442 @default.
• W1977247124 hasRelatedWork W2350886079 @default.
• W1977247124 hasRelatedWork W2374660189 @default.
• W1977247124 hasRelatedWork W4364352257 @default.
• W1977247124 hasVolume "8" @default.
• W1977247124 isParatext "false" @default.
• W1977247124 isRetracted "false" @default.
• W1977247124 magId "1977247124" @default.
• W1977247124 workType "article" @default.