FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977259610> ?p ?o ?g. }

• W1977259610 endingPage "7970" @default.
• W1977259610 startingPage "7962" @default.
• W1977259610 abstract "Abstract Hepatocyte growth factor/scatter factor-Met signaling has been implicated in tumor growth, invasion, and metastasis. Suppression of this signaling pathway by targeting the Met protein tyrosine kinase may be an ideal strategy for suppressing malignant tumor growth. Using RNA interference technology and adenovirus vectors carrying small-interfering RNA constructs (Ad Met small-interfering RNA) directed against mouse, canine, and human Met, we can knock down c-met mRNA. We show a dramatic dependence on Met in both ligand-dependent and ligand-independent mouse, canine, and human tumor cell lines. Mouse mammary tumor (DA3) cells and Met-transformed NIH3T3 (M114) cells, as well as both human and canine prostate cancer (PC-3 and TR6LM, human sarcoma (SK-LMS-1), glioblastoma (DBTRG), and gastric cancer (MKN45) cells, all display a dramatic reduction of Met expression after infection with Ad Met small-interfering RNA. In these cells, we observe suppression of tumor cell growth and viability in vitro as well as inhibition of hepatocyte growth factor/scatter factor-mediated scattering and invasion in vitro, whether Met activation was ligand dependent or not. Importantly, Ad Met small-interfering RNA led to apoptotic cell death in many of the tumor cell lines, especially DA3 and MKN45, but did not adversely affect MDCK canine kidney cells. Met small-interfering RNA also abrogated downstream Met signaling to molecules such as Akt and p44/42 mitogen-activated protein kinase. We further show that intratumoral infection with c-met small-interfering RNA adenovirus results in a substantial reduction in tumor growth. Thus, Met small-interfering RNA adenoviruses are reliable tools for studying Met function and raise the possibility of their application for cancer therapy." @default.
• W1977259610 created "2016-06-24" @default.
• W1977259610 creator A5012426378 @default.
• W1977259610 creator A5016038041 @default.
• W1977259610 creator A5041766764 @default.
• W1977259610 creator A5044110781 @default.
• W1977259610 creator A5048925301 @default.
• W1977259610 creator A5052960352 @default.
• W1977259610 creator A5091344747 @default.
• W1977259610 date "2004-11-01" @default.
• W1977259610 modified "2023-10-03" @default.
• W1977259610 title "RNA Interference Reveals that Ligand-Independent Met Activity Is Required for Tumor Cell Signaling and Survival" @default.
• W1977259610 cites W1488192195 @default.
• W1977259610 cites W1506304328 @default.
• W1977259610 cites W1535671294 @default.
• W1977259610 cites W1551448311 @default.
• W1977259610 cites W1611419331 @default.
• W1977259610 cites W1647075334 @default.
• W1977259610 cites W1973966923 @default.
• W1977259610 cites W1974861468 @default.
• W1977259610 cites W1978514461 @default.
• W1977259610 cites W1979165798 @default.
• W1977259610 cites W1981550662 @default.
• W1977259610 cites W1991346159 @default.
• W1977259610 cites W1992220862 @default.
• W1977259610 cites W1996163490 @default.
• W1977259610 cites W2011717936 @default.
• W1977259610 cites W2012792646 @default.
• W1977259610 cites W2019871776 @default.
• W1977259610 cites W2024164686 @default.
• W1977259610 cites W2045115099 @default.
• W1977259610 cites W2048797151 @default.
• W1977259610 cites W2050983091 @default.
• W1977259610 cites W2055262054 @default.
• W1977259610 cites W2067928188 @default.
• W1977259610 cites W2072543946 @default.
• W1977259610 cites W2093264762 @default.
• W1977259610 cites W2094752726 @default.
• W1977259610 cites W2099541633 @default.
• W1977259610 cites W2101722758 @default.
• W1977259610 cites W2108330459 @default.
• W1977259610 cites W2124972064 @default.
• W1977259610 cites W2126890008 @default.
• W1977259610 cites W2128394438 @default.
• W1977259610 cites W2130083086 @default.
• W1977259610 cites W2132831751 @default.
• W1977259610 cites W2136390065 @default.
• W1977259610 cites W2139440398 @default.
• W1977259610 cites W2145638174 @default.
• W1977259610 cites W2146900615 @default.
• W1977259610 cites W2149902890 @default.
• W1977259610 cites W2164653061 @default.
• W1977259610 cites W2166927748 @default.
• W1977259610 cites W2168918909 @default.
• W1977259610 cites W2328659017 @default.
• W1977259610 doi "https://doi.org/10.1158/0008-5472.can-04-1043" @default.
• W1977259610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15520203" @default.
• W1977259610 hasPublicationYear "2004" @default.
• W1977259610 type Work @default.
• W1977259610 sameAs 1977259610 @default.
• W1977259610 citedByCount "96" @default.
• W1977259610 countsByYear W19772596102012 @default.
• W1977259610 countsByYear W19772596102013 @default.
• W1977259610 countsByYear W19772596102014 @default.
• W1977259610 countsByYear W19772596102015 @default.
• W1977259610 countsByYear W19772596102016 @default.
• W1977259610 countsByYear W19772596102017 @default.
• W1977259610 countsByYear W19772596102018 @default.
• W1977259610 countsByYear W19772596102020 @default.
• W1977259610 countsByYear W19772596102021 @default.
• W1977259610 countsByYear W19772596102022 @default.
• W1977259610 crossrefType "journal-article" @default.
• W1977259610 hasAuthorship W1977259610A5012426378 @default.
• W1977259610 hasAuthorship W1977259610A5016038041 @default.
• W1977259610 hasAuthorship W1977259610A5041766764 @default.
• W1977259610 hasAuthorship W1977259610A5044110781 @default.
• W1977259610 hasAuthorship W1977259610A5048925301 @default.
• W1977259610 hasAuthorship W1977259610A5052960352 @default.
• W1977259610 hasAuthorship W1977259610A5091344747 @default.
• W1977259610 hasConcept C104317684 @default.
• W1977259610 hasConcept C153911025 @default.
• W1977259610 hasConcept C166703698 @default.
• W1977259610 hasConcept C170493617 @default.
• W1977259610 hasConcept C22615655 @default.
• W1977259610 hasConcept C2776996007 @default.
• W1977259610 hasConcept C502942594 @default.
• W1977259610 hasConcept C54009773 @default.
• W1977259610 hasConcept C54355233 @default.
• W1977259610 hasConcept C55493867 @default.
• W1977259610 hasConcept C62112901 @default.
• W1977259610 hasConcept C62478195 @default.
• W1977259610 hasConcept C67705224 @default.
• W1977259610 hasConcept C75217442 @default.
• W1977259610 hasConcept C81885089 @default.
• W1977259610 hasConcept C86803240 @default.
• W1977259610 hasConcept C95444343 @default.
• W1977259610 hasConceptScore W1977259610C104317684 @default.
• W1977259610 hasConceptScore W1977259610C153911025 @default.

• next