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• W1977277568 abstract "Ten years ago we showed for the first time that Notch signalling is required in segmentation in spiders, indicating the existence of similar mechanisms in arthropod and vertebrate segmentation. However, conflicting results in various arthropod groups hampered our understanding of the ancestral function of Notch in arthropod segmentation. Here we fill a crucial data gap in arthropods and analyse segmentation in a crustacean embryo. We analyse the expression of homologues of the Drosophila and vertebrate segmentation genes and show that members of the Notch signalling pathway are expressed at the same time as the pair-rule genes. Furthermore, inactivation of Notch signalling results in irregular boundaries of the odd-skipped-like expression domains and affects the formation of segments. In severe cases embryos appear unsegmented. We suggest two scenarios for the function of Notch signalling in segmentation. The first scenario agrees with a segmentation clock involving Notch signalling, while the second scenario discusses an alternative mechanism of Notch function which is integrated into a hierarchical segmentation cascade." @default.
• W1977277568 created "2016-06-24" @default.
• W1977277568 creator A5001555599 @default.
• W1977277568 creator A5041535588 @default.
• W1977277568 creator A5041830351 @default.
• W1977277568 date "2013-11-01" @default.
• W1977277568 modified "2023-09-23" @default.
• W1977277568 title "The function of Notch signalling in segment formation in the crustacean Daphnia magna (Branchiopoda)" @default.
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• W1977277568 doi "https://doi.org/10.1016/j.ydbio.2013.09.021" @default.
• W1977277568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24063806" @default.
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