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- W1977289924 abstract "A study was made in order to investigate if any clinical difference could be found between the effects of several digitalis and digitalis-like preparations.The drugs used were digitaline (digitoxin), acylanid (acetyl-digitoxin), lanoxin (digoxin), cedilanid D (deacetylated-lanatoside C), gitaligin (gitalin), and ouabain.These drugs were administered to 162 cases (138 suffering from heart failure and 24 controls) by intravenous injections (intramuscular in some). Full digitalization was obtained within two to four days with comparable doses. Clinical data, venous pressure and circulation times, roentgenologic and electrocardiographic data, were noted for seven days.A method of rating the effect of the drugs in the individual cases is described.The dose which is effective for intravenous digitalization is described for each drug on the basis of the present study. This total dose was ascertained by subtracting the average daily eliminated dose from the total received.The greatest effect on heart rate was obtained with digoxin and cedilanid.The greatest rapidity of effect was obtained with ouabain followed by digitoxin.The greatest decrease of signs of congestion was obtained with digitoxin, acetyl-digitoxin or digoxin.The greatest decrease of cardiac size was obtained with digitoxin or acetyl-digitoxin. This does not confirm previous studies of the authors according to which ouabain would exert a greater action than the above glycosides.The greatest changes of the electrocardiogram were exerted by digitoxin; the smallest, by cedilanid. This was considered as a point in favor of the latter.The greatest toxicity was found with digoxin while digitoxin did not seem to present special problems.Gitalin seems to have an intermediate position from the various points of view.The overall rating of the glycosides is discussed. This, however, should not be unduly stressed, as special indications were found for several glycosides." @default.
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- W1977289924 date "1958-06-01" @default.
- W1977289924 modified "2023-09-27" @default.
- W1977289924 title "Clinical comparison of six digitalis preparations by the parenteral route" @default.
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- W1977289924 doi "https://doi.org/10.1016/0002-9149(58)90160-7" @default.
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