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• W1977290785 abstract "The association of diabetes mellitus with prostate cancer has been controversial. This study examines the strength of this association by conducting a detailed meta-analysis of the studies published in peer-reviewed literature on the subject. A comprehensive search for articles published up to 2003 was performed, reviews of each study were conducted and data were abstracted. Prior to meta-analysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk (RR) was calculated using the random- and the fixed-effects models. Subgroup and sensitivity analyses were also performed. We included 14 studies, published between 1971 and 2002, in the meta-analysis (five case-control studies, nine cohort studies). We found no evidence of publication bias (p=0.89) or heterogeneity among the studies (p=0.38). The association of diabetes with prostate cancer was statistically significant, both on the basis of a random-effects model (RR=0.91, 95% CI: 0.86 to 0.96), and on the basis of a fixed-effects model (RR=0.91, 95% CI: 0.88 to 0.94). When the analysis was stratified into subgroups according to study design, the association was inverse in both cohort and case-control studies, but only in the former was it statistically significant. The sensitivity analysis strengthened our confidence in the validity of this association. Our meta-analysis findings provide strong evidence that people with diabetes have a significant decrease in risk of developing prostate cancer. There is biological evidence to support this association." @default.
• W1977290785 created "2016-06-24" @default.
• W1977290785 creator A5008725400 @default.
• W1977290785 creator A5035396974 @default.
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• W1977290785 date "2004-05-26" @default.
• W1977290785 modified "2023-10-17" @default.
• W1977290785 title "Diabetes mellitus and risk of prostate cancer: a meta-analysis" @default.
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• W1977290785 doi "https://doi.org/10.1007/s00125-004-1415-6" @default.
• W1977290785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15164171" @default.
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