FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977292749> ?p ?o ?g. }

• W1977292749 endingPage "1490" @default.
• W1977292749 startingPage "1483" @default.
• W1977292749 abstract "Microvascular injury plays a key role in normal tissue radiation responses. Statins, in addition to their lipid-lowering effects, have vasculoprotective properties that may counteract some effects of radiation on normal tissues. We examined whether administration of simvastatin ameliorates intestinal radiation injury, and whether the effect depends on protein C activation.Rats received localized, fractionated small bowel irradiation. The animals were fed either regular chow or chow containing simvastatin from 2 weeks before irradiation until termination of the experiment. Groups of rats were euthanized at 2 weeks and 26 weeks for assessment of early and delayed radiation injury by quantitative histology, morphometry, and quantitative immunohistochemistry. Dependency on protein C activation was examined in thrombomodulin (TM) mutant mice with deficient ability to activate protein C.Simvastatin administration was associated with lower radiation injury scores (p < 0.0001), improved mucosal preservation (p = 0.0009), and reduced thickening of the intestinal wall and subserosa (p = 0.008 and p = 0.004), neutrophil infiltration (p = 0.04), and accumulation of collagen I (p = 0.0003). The effect of simvastatin was consistently more pronounced for delayed than for early injury. Surprisingly, simvastatin reduced intestinal radiation injury in TM mutant mice, indicating that the enteroprotective effect of simvastatin after localized irradiation is unrelated to protein C activation.Simvastatin ameliorates the intestinal radiation response. The radioprotective effect of simvastatin after localized small bowel irradiation does not appear to be related to protein C activation. Statins should undergo clinical testing as a strategy to minimize side effects of radiation on the intestine and other normal tissues." @default.
• W1977292749 created "2016-06-24" @default.
• W1977292749 creator A5006415224 @default.
• W1977292749 creator A5014015669 @default.
• W1977292749 creator A5046236881 @default.
• W1977292749 creator A5070492895 @default.
• W1977292749 creator A5088241361 @default.
• W1977292749 creator A5091449087 @default.
• W1977292749 date "2007-08-01" @default.
• W1977292749 modified "2023-10-18" @default.
• W1977292749 title "Simvastatin Ameliorates Radiation Enteropathy Development After Localized, Fractionated Irradiation by a Protein C-Independent Mechanism" @default.
• W1977292749 cites W148055779 @default.
• W1977292749 cites W1832540901 @default.
• W1977292749 cites W1966662632 @default.
• W1977292749 cites W1968608979 @default.
• W1977292749 cites W1988584002 @default.
• W1977292749 cites W2004379308 @default.
• W1977292749 cites W2005463486 @default.
• W1977292749 cites W2014237668 @default.
• W1977292749 cites W2014690275 @default.
• W1977292749 cites W2015703244 @default.
• W1977292749 cites W2016658054 @default.
• W1977292749 cites W2019850173 @default.
• W1977292749 cites W2020894250 @default.
• W1977292749 cites W2022594329 @default.
• W1977292749 cites W2025724503 @default.
• W1977292749 cites W2027214733 @default.
• W1977292749 cites W2027983826 @default.
• W1977292749 cites W2031077003 @default.
• W1977292749 cites W2034079981 @default.
• W1977292749 cites W2035404114 @default.
• W1977292749 cites W2044351980 @default.
• W1977292749 cites W2049245042 @default.
• W1977292749 cites W2053669774 @default.
• W1977292749 cites W2059310347 @default.
• W1977292749 cites W2069901637 @default.
• W1977292749 cites W2074465835 @default.
• W1977292749 cites W2074982398 @default.
• W1977292749 cites W2077103009 @default.
• W1977292749 cites W2086752041 @default.
• W1977292749 cites W2096801164 @default.
• W1977292749 cites W2098098743 @default.
• W1977292749 cites W2100953923 @default.
• W1977292749 cites W2102319255 @default.
• W1977292749 cites W2103636227 @default.
• W1977292749 cites W2104339533 @default.
• W1977292749 cites W2106415446 @default.
• W1977292749 cites W2114150652 @default.
• W1977292749 cites W2118399490 @default.
• W1977292749 cites W2121951682 @default.
• W1977292749 cites W2132394283 @default.
• W1977292749 cites W2145448066 @default.
• W1977292749 cites W2148654700 @default.
• W1977292749 cites W2155853522 @default.
• W1977292749 cites W2166862308 @default.
• W1977292749 cites W2166970179 @default.
• W1977292749 cites W2174608167 @default.
• W1977292749 cites W2314564809 @default.
• W1977292749 cites W2328363504 @default.
• W1977292749 cites W2397202868 @default.
• W1977292749 cites W2401200720 @default.
• W1977292749 cites W2427949383 @default.
• W1977292749 doi "https://doi.org/10.1016/j.ijrobp.2007.03.036" @default.
• W1977292749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2000701" @default.
• W1977292749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17674978" @default.
• W1977292749 hasPublicationYear "2007" @default.
• W1977292749 type Work @default.
• W1977292749 sameAs 1977292749 @default.
• W1977292749 citedByCount "70" @default.
• W1977292749 countsByYear W19772927492012 @default.
• W1977292749 countsByYear W19772927492013 @default.
• W1977292749 countsByYear W19772927492014 @default.
• W1977292749 countsByYear W19772927492015 @default.
• W1977292749 countsByYear W19772927492016 @default.
• W1977292749 countsByYear W19772927492017 @default.
• W1977292749 countsByYear W19772927492018 @default.
• W1977292749 countsByYear W19772927492019 @default.
• W1977292749 countsByYear W19772927492021 @default.
• W1977292749 countsByYear W19772927492023 @default.
• W1977292749 crossrefType "journal-article" @default.
• W1977292749 hasAuthorship W1977292749A5006415224 @default.
• W1977292749 hasAuthorship W1977292749A5014015669 @default.
• W1977292749 hasAuthorship W1977292749A5046236881 @default.
• W1977292749 hasAuthorship W1977292749A5070492895 @default.
• W1977292749 hasAuthorship W1977292749A5088241361 @default.
• W1977292749 hasAuthorship W1977292749A5091449087 @default.
• W1977292749 hasBestOaLocation W19772927492 @default.
• W1977292749 hasConcept C126322002 @default.
• W1977292749 hasConcept C134018914 @default.
• W1977292749 hasConcept C142724271 @default.
• W1977292749 hasConcept C2776329913 @default.
• W1977292749 hasConcept C71924100 @default.
• W1977292749 hasConceptScore W1977292749C126322002 @default.
• W1977292749 hasConceptScore W1977292749C134018914 @default.
• W1977292749 hasConceptScore W1977292749C142724271 @default.
• W1977292749 hasConceptScore W1977292749C2776329913 @default.
• W1977292749 hasConceptScore W1977292749C71924100 @default.
• W1977292749 hasIssue "5" @default.

• next