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- W1977314787 abstract "HCV-Ag-specific TH17 cells secrete IL17, a cytokine involved in autoimmune diseases and regulated by IL10 and TGF-b. 5–12% of patients with chronic HCV infection have hypothyroidism. We evaluated the role of these cytokines in this patients by determining serum concentration of TsH, T3, free T4, IL2, IL10, IL12, IL17, TGF-b, anti-TG, TPO, CCP, GBM, and cardiolipin antibodies in 87 chronically noninterferon treated HCV-infected patients. 20 patients (group A) had elevated TsH values (>5 <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>μ</mml:mi></mml:math>UI/ml) whereas the remaining 67 (group B) had normal values. The percentage of anti-TPO, TG, GBM, and cardiolipin antibodies in group A patients (33%, 41%, 5% and 5%, resp.) as well as IL17, IL2 and TGF-b concentrations (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mn>25</mml:mn><mml:mo>±</mml:mo><mml:mn>23</mml:mn></mml:math> pg/ml, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mn>643</mml:mn><mml:mo>±</mml:mo><mml:mn>572</mml:mn></mml:math> pg/ml, and <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mn>618</mml:mn><mml:mo>±</mml:mo><mml:mn>221</mml:mn></mml:math> pg/ml, resp.) were significantly higher than group B. Abnormal Th17 regulation mediated by IL-2 and low TGF-b concentrations is associated with hypothyroidism in chronically-infected HCV patients." @default.
- W1977314787 created "2016-06-24" @default.
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- W1977314787 date "2010-03-08" @default.
- W1977314787 modified "2023-10-15" @default.
- W1977314787 title "Hypothyroidism in Noninterferon Treated-HCV Infected Individuals Is Associated with Abnormalities in the Regulation of Th17 Cells" @default.
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- W1977314787 doi "https://doi.org/10.1155/2010/971095" @default.
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