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• W1977326369 abstract "Chlamydia pneumoniae can infect arterial cells. It has been shown that coculture of human monocytes (U937) and endothelial cells promotes infection of C. pneumoniae in endothelial cells and that the enhancement was mediated by a soluble factor (insulin-like growth factor 2) secreted by monocytes. In this study, it is shown that coculture of monocytes with C. pneumoniae enhances infection of C. pneumoniae in arterial smooth-muscle cells 5.3-fold at a monocyte-to-smooth-muscle cell ratio of 5. However, unlike endothelial cells, no enhancement was observed if monocytes were placed in cell culture inserts or if conditioned medium from monocyte cultures was used, which suggests that cell-to-cell contact is critical. The addition of mannose 6-phosphate or octyl glucoside, a nonionic detergent containing a sugar group, to cocultures inhibited the enhancement. These findings suggest that the monocyte-smooth-muscle cell interaction may be mediated by mannose 6-phosphate receptors present on monocytes." @default.
• W1977326369 created "2016-06-24" @default.
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• W1977326369 date "2003-02-01" @default.
• W1977326369 modified "2023-10-13" @default.
• W1977326369 title "Cell‐to‐Cell Contact of Human Monocytes with Infected Arterial Smooth‐Muscle Cells Enhances Growth of<i>Chlamydia pneumoniae</i>" @default.
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• W1977326369 doi "https://doi.org/10.1086/368267" @default.
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