FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977331848> ?p ?o ?g. }

• W1977331848 abstract "A common single nucleotide polymorphism in the E-selectin (SELE) gene S149R results in the loss of E-selectin ligand binding specificity. The 149R allele has been associated with severe cardiovascular diseases. We hypothesized that S149R may regulate platelet activation after stimuli associated with perioperative procedures in patients undergoing isolated coronary artery bypass grafting (CABG). Associations between the S149R polymorphism and an increased risk of perioperative acute thrombotic events with regards to a platelet count and activity were analyzed.In elective CABG patients (n = 152) we analyzed associations between S149R polymorphism and an increased risk of perioperative acute thrombotic events with regard to platelet count and activity. The S149R SELE gene polymorphism was determined by real-time polymerase chain reaction. Platelet count and activation marker (β-thromboglobulin-βTG) were evaluated.Prevalence of the S149R genotypes was as follows: 81.8% (n = 121) of homozygotes (149SS), 15.5% (n = 23) of heterozygotes and 2.7% (n = 4) of homozygotes (149RR). The 149R allele carriers had significantly higher postoperative βTG levels than the homozygotes (97 [79-120] vs. 76 [66-91] IU/mL, p = 0.03). Sixteen patients had adverse events: myocardial infarction (n = 14), stroke (n = 1) and fatal pulmonary embolism (n = 1). Twelve patients were carriers of the 149R allele. Relative risk (RR) of postoperative adverse events in the 149R allele carriers was 2.03 with 95% CI (1.05-3.03).Postoperative platelet activation is related to the S149R polymorphism, which enhances the risk of adverse events after CABG." @default.
• W1977331848 created "2016-06-24" @default.
• W1977331848 creator A5015433917 @default.
• W1977331848 creator A5027629334 @default.
• W1977331848 creator A5028620962 @default.
• W1977331848 creator A5052251497 @default.
• W1977331848 creator A5055304506 @default.
• W1977331848 creator A5072453639 @default.
• W1977331848 creator A5089364840 @default.
• W1977331848 creator A5090813957 @default.
• W1977331848 date "2011-07-01" @default.
• W1977331848 modified "2023-10-05" @default.
• W1977331848 title "Effect of the E-selectin Gene Polymorphism (S149R) on Platelet Activation and Adverse Events After Coronary Artery Surgery" @default.
• W1977331848 cites W1978537999 @default.
• W1977331848 cites W1985531383 @default.
• W1977331848 cites W1994159589 @default.
• W1977331848 cites W2001097358 @default.
• W1977331848 cites W2003466007 @default.
• W1977331848 cites W2032319834 @default.
• W1977331848 cites W2044918480 @default.
• W1977331848 cites W2055563833 @default.
• W1977331848 cites W2064439163 @default.
• W1977331848 cites W2088407768 @default.
• W1977331848 cites W2098507195 @default.
• W1977331848 cites W2098576266 @default.
• W1977331848 cites W2106208034 @default.
• W1977331848 cites W2121800004 @default.
• W1977331848 cites W2135849820 @default.
• W1977331848 cites W2138612542 @default.
• W1977331848 cites W2145971433 @default.
• W1977331848 cites W2158220397 @default.
• W1977331848 cites W2310916660 @default.
• W1977331848 cites W2399648151 @default.
• W1977331848 cites W2435437063 @default.
• W1977331848 doi "https://doi.org/10.1016/j.arcmed.2011.07.007" @default.
• W1977331848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21827804" @default.
• W1977331848 hasPublicationYear "2011" @default.
• W1977331848 type Work @default.
• W1977331848 sameAs 1977331848 @default.
• W1977331848 citedByCount "12" @default.
• W1977331848 countsByYear W19773318482012 @default.
• W1977331848 countsByYear W19773318482014 @default.
• W1977331848 countsByYear W19773318482015 @default.
• W1977331848 countsByYear W19773318482016 @default.
• W1977331848 crossrefType "journal-article" @default.
• W1977331848 hasAuthorship W1977331848A5015433917 @default.
• W1977331848 hasAuthorship W1977331848A5027629334 @default.
• W1977331848 hasAuthorship W1977331848A5028620962 @default.
• W1977331848 hasAuthorship W1977331848A5052251497 @default.
• W1977331848 hasAuthorship W1977331848A5055304506 @default.
• W1977331848 hasAuthorship W1977331848A5072453639 @default.
• W1977331848 hasAuthorship W1977331848A5089364840 @default.
• W1977331848 hasAuthorship W1977331848A5090813957 @default.
• W1977331848 hasConcept C104317684 @default.
• W1977331848 hasConcept C126322002 @default.
• W1977331848 hasConcept C135763542 @default.
• W1977331848 hasConcept C153471976 @default.
• W1977331848 hasConcept C164705383 @default.
• W1977331848 hasConcept C180754005 @default.
• W1977331848 hasConcept C197934379 @default.
• W1977331848 hasConcept C3018697912 @default.
• W1977331848 hasConcept C31174226 @default.
• W1977331848 hasConcept C42219234 @default.
• W1977331848 hasConcept C500558357 @default.
• W1977331848 hasConcept C54355233 @default.
• W1977331848 hasConcept C71924100 @default.
• W1977331848 hasConcept C86803240 @default.
• W1977331848 hasConcept C89560881 @default.
• W1977331848 hasConcept C90924648 @default.
• W1977331848 hasConceptScore W1977331848C104317684 @default.
• W1977331848 hasConceptScore W1977331848C126322002 @default.
• W1977331848 hasConceptScore W1977331848C135763542 @default.
• W1977331848 hasConceptScore W1977331848C153471976 @default.
• W1977331848 hasConceptScore W1977331848C164705383 @default.
• W1977331848 hasConceptScore W1977331848C180754005 @default.
• W1977331848 hasConceptScore W1977331848C197934379 @default.
• W1977331848 hasConceptScore W1977331848C3018697912 @default.
• W1977331848 hasConceptScore W1977331848C31174226 @default.
• W1977331848 hasConceptScore W1977331848C42219234 @default.
• W1977331848 hasConceptScore W1977331848C500558357 @default.
• W1977331848 hasConceptScore W1977331848C54355233 @default.
• W1977331848 hasConceptScore W1977331848C71924100 @default.
• W1977331848 hasConceptScore W1977331848C86803240 @default.
• W1977331848 hasConceptScore W1977331848C89560881 @default.
• W1977331848 hasConceptScore W1977331848C90924648 @default.
• W1977331848 hasLocation W19773318481 @default.
• W1977331848 hasLocation W19773318482 @default.
• W1977331848 hasOpenAccess W1977331848 @default.
• W1977331848 hasPrimaryLocation W19773318481 @default.
• W1977331848 hasRelatedWork W1600697118 @default.
• W1977331848 hasRelatedWork W1976954262 @default.
• W1977331848 hasRelatedWork W2021269994 @default.
• W1977331848 hasRelatedWork W2042744434 @default.
• W1977331848 hasRelatedWork W2044901769 @default.
• W1977331848 hasRelatedWork W2076865386 @default.
• W1977331848 hasRelatedWork W2081052757 @default.
• W1977331848 hasRelatedWork W2093791464 @default.
• W1977331848 hasRelatedWork W2098044444 @default.
• W1977331848 hasRelatedWork W2116475791 @default.
• W1977331848 hasRelatedWork W2130396542 @default.

• next