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• W1977333429 abstract "Synaptic plasticity in many regions of the central nervous system leads to the continuous adjustment of synaptic strength, which is essential for learning and memory. In this study, we show by visualizing synaptic vesicle release in mouse hippocampal synaptosomes that presynaptic mitochondria and, specifically, their capacities for ATP production are essential determinants of synaptic vesicle exocytosis and its magnitude. Total internal reflection microscopy of FM1-43 loaded hippocampal synaptosomes showed that inhibition of mitochondrial oxidative phosphorylation reduces evoked synaptic release. This reduction was accompanied by a substantial drop in synaptosomal ATP levels. However, cytosolic calcium influx was not affected. Structural characterization of stimulated hippocampal synaptosomes revealed that higher total presynaptic mitochondrial volumes were consistently associated with higher levels of exocytosis. Thus, synaptic vesicle release is linked to the presynaptic ability to regenerate ATP, which itself is a utility of mitochondrial density and activity." @default.
• W1977333429 created "2016-06-24" @default.
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• W1977333429 creator A5014647586 @default.
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• W1977333429 date "2012-07-08" @default.
• W1977333429 modified "2023-09-27" @default.
• W1977333429 title "Synaptic Vesicle Exocytosis in Hippocampal Synaptosomes Correlates Directly with Total Mitochondrial Volume" @default.
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• W1977333429 doi "https://doi.org/10.1007/s12031-012-9848-8" @default.
• W1977333429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3488359" @default.
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