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• W1977338297 abstract "A method based on HPLC was devised for the estimation of RU 486 in blood and utilised to study the pharmacokinetics of a single dose of 50 mg RU 486 administered orally to 12 women on day 7 of the cycle. The dose was rapidly absorbed with peak plasma concentration between 1 and 2 hours. Distribution was also rapid (mean t1/2 alpha: 1.4h), whereas elimination was slow (mean t1/2 beta: 28.3 h). RU 486 was still detectable in some women at 72 h after administration. The plasma concentrations fitted the equation for a two-compartment open model from which the pharmacokinetic parameters were calculated. The mean total plasma clearance was 3.0 l/h, and the comparison of our data with those published studies suggests that the pharmacokinetics of RU 486 in Chinese women are similar to those of other populations.A method based on high performance liquid chromatography (HPLC) was developed for the estimation of RU-486 in blood and used to analyze the pharmacokinetics of a single dose of 50 mg of RU-486 administered orally to 12 Chinese women on day 7 of the menstrual cycle. In the 1st 6 subjects, blood samples were taken immediately before and 1, 2, 4, 8, 24, and 48 hours after RU-486 administration; in the 2nd group of 6 women, additional samples were taken at 0.33, 0.5, 0.75, and 72 hours. Since there were no significant differences between the 2 groups in values, the data were combined. RU-486 was found to be rapidly absorbed, with significant amounts present in the 20 minute samples and peak concentrations at 1-2 hours. In contrast, elimination was slow and significant levels of RU-486 were still detectable in most subjects at 72 hours. The mean value for the half-life of absorption was less than 1 hour, while the mean half-life of distribution was 1.4 hours. Mean total plasma clearance was 3.0 liters/hour. The plasma concentrations fitted the equation for a 2-compartment open model from which the pharmacokinetic parameters were calculated. Comparison of these findings with those from other studies suggest that the pharmacokinetics of RU-486 in Chinese women are similar to those in non-Asian populations." @default.
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• W1977338297 date "1989-10-01" @default.
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• W1977338297 title "Pharmacokinetic study of orally administered RU 486 in non-pregnant women" @default.
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• W1977338297 doi "https://doi.org/10.1016/0010-7824(89)90052-8" @default.
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