FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977351617> ?p ?o ?g. }

• W1977351617 endingPage "588" @default.
• W1977351617 startingPage "584" @default.
• W1977351617 abstract "Omega-3 and omega-6 poly-unsaturated fatty acids (PUFAs) are dietary fatty acids that are involved in a myriad of physiological processes in the brain. Although experimental data have shown that PUFAs have anticonvulsant properties, the outcomes of clinical trials have been controversial. Docosahexaenoic acid (DHA) is a PUFA which has been reported to exert anticonvulsant effects. Here we studied anticonvulsant potential of a mixture of enriched n-3 PUFA upon their oral administration in rats. We did not observe an anticonvulsant effect of n-3 PUFA in the i.v. pentylentetrazol threshold test. n-3 PUFA component was increased in the plasma of rats treated with the eicosapentaenoic acid (EPA)/DHA mix (275 mg/kg/d/400 mg/kg/d) due to the increase of both DHA and EPA. We also found modification of PUFA composition in the brain. Despite PUFA profiles modified both in plasma and in the brain, we did not find any anticonvulsant effect of orally administered DHA. Further studies are needed to define the type and the amount of fatty acids that would possess anticonvulsant properties. As the existing literature suggests that the route of administration of PUFA may be crucial, future studies should involve oral administration to provide relevant clinical information." @default.
• W1977351617 created "2016-06-24" @default.
• W1977351617 creator A5028474858 @default.
• W1977351617 creator A5033474449 @default.
• W1977351617 creator A5035129860 @default.
• W1977351617 creator A5050726404 @default.
• W1977351617 creator A5065185262 @default.
• W1977351617 creator A5069122824 @default.
• W1977351617 creator A5070822618 @default.
• W1977351617 date "2011-12-01" @default.
• W1977351617 modified "2023-10-16" @default.
• W1977351617 title "Oral Administration of Docosahexaenoic Acid/Eicosapentaeinoic Acids Is Not Anticonvulsant in Rats: Implications for Translational Research" @default.
• W1977351617 cites W1532082124 @default.
• W1977351617 cites W1595651229 @default.
• W1977351617 cites W1787497562 @default.
• W1977351617 cites W1973549805 @default.
• W1977351617 cites W1973611043 @default.
• W1977351617 cites W1975332428 @default.
• W1977351617 cites W2002102734 @default.
• W1977351617 cites W2002131557 @default.
• W1977351617 cites W2010224190 @default.
• W1977351617 cites W2011578117 @default.
• W1977351617 cites W2013041263 @default.
• W1977351617 cites W2013051077 @default.
• W1977351617 cites W2027404042 @default.
• W1977351617 cites W2041445916 @default.
• W1977351617 cites W2045757864 @default.
• W1977351617 cites W2047735187 @default.
• W1977351617 cites W2049447364 @default.
• W1977351617 cites W2049617752 @default.
• W1977351617 cites W2055715934 @default.
• W1977351617 cites W2066059769 @default.
• W1977351617 cites W2067686370 @default.
• W1977351617 cites W2071334323 @default.
• W1977351617 cites W2073559330 @default.
• W1977351617 cites W2076656233 @default.
• W1977351617 cites W2084535203 @default.
• W1977351617 cites W2093194534 @default.
• W1977351617 cites W2116757115 @default.
• W1977351617 cites W2126403835 @default.
• W1977351617 cites W2126594232 @default.
• W1977351617 cites W2133858157 @default.
• W1977351617 cites W2152311269 @default.
• W1977351617 cites W2163232985 @default.
• W1977351617 cites W4252035275 @default.
• W1977351617 doi "https://doi.org/10.1203/pdr.0b013e31823277d9" @default.
• W1977351617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21857379" @default.
• W1977351617 hasPublicationYear "2011" @default.
• W1977351617 type Work @default.
• W1977351617 sameAs 1977351617 @default.
• W1977351617 citedByCount "6" @default.
• W1977351617 countsByYear W19773516172012 @default.
• W1977351617 countsByYear W19773516172013 @default.
• W1977351617 countsByYear W19773516172015 @default.
• W1977351617 countsByYear W19773516172016 @default.
• W1977351617 crossrefType "journal-article" @default.
• W1977351617 hasAuthorship W1977351617A5028474858 @default.
• W1977351617 hasAuthorship W1977351617A5033474449 @default.
• W1977351617 hasAuthorship W1977351617A5035129860 @default.
• W1977351617 hasAuthorship W1977351617A5050726404 @default.
• W1977351617 hasAuthorship W1977351617A5065185262 @default.
• W1977351617 hasAuthorship W1977351617A5069122824 @default.
• W1977351617 hasAuthorship W1977351617A5070822618 @default.
• W1977351617 hasBestOaLocation W19773516171 @default.
• W1977351617 hasConcept C118552586 @default.
• W1977351617 hasConcept C185592680 @default.
• W1977351617 hasConcept C19038510 @default.
• W1977351617 hasConcept C2775858608 @default.
• W1977351617 hasConcept C2776091944 @default.
• W1977351617 hasConcept C2777056448 @default.
• W1977351617 hasConcept C2777171753 @default.
• W1977351617 hasConcept C2778186239 @default.
• W1977351617 hasConcept C543025807 @default.
• W1977351617 hasConcept C55493867 @default.
• W1977351617 hasConcept C71924100 @default.
• W1977351617 hasConcept C98274493 @default.
• W1977351617 hasConceptScore W1977351617C118552586 @default.
• W1977351617 hasConceptScore W1977351617C185592680 @default.
• W1977351617 hasConceptScore W1977351617C19038510 @default.
• W1977351617 hasConceptScore W1977351617C2775858608 @default.
• W1977351617 hasConceptScore W1977351617C2776091944 @default.
• W1977351617 hasConceptScore W1977351617C2777056448 @default.
• W1977351617 hasConceptScore W1977351617C2777171753 @default.
• W1977351617 hasConceptScore W1977351617C2778186239 @default.
• W1977351617 hasConceptScore W1977351617C543025807 @default.
• W1977351617 hasConceptScore W1977351617C55493867 @default.
• W1977351617 hasConceptScore W1977351617C71924100 @default.
• W1977351617 hasConceptScore W1977351617C98274493 @default.
• W1977351617 hasIssue "6" @default.
• W1977351617 hasLocation W19773516171 @default.
• W1977351617 hasLocation W19773516172 @default.
• W1977351617 hasOpenAccess W1977351617 @default.
• W1977351617 hasPrimaryLocation W19773516171 @default.
• W1977351617 hasRelatedWork W1977351617 @default.
• W1977351617 hasRelatedWork W1990478119 @default.
• W1977351617 hasRelatedWork W2002621906 @default.
• W1977351617 hasRelatedWork W2004692907 @default.
• W1977351617 hasRelatedWork W2027404042 @default.

• next