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- W1977373357 abstract "El hiperparatiroidismo primario (HPP) es una enfermedad endocrinológica frecuente, caracterizada por una secreción excesiva de hormona paratiroidea (PTH) que produce generalmente hipercalcemia y un conjunto de manifestaciones clínicas variables. Las manifestaciones específicas son la nefrolitiasis y la osteítis fibrosa quística, que caracterizan el fenotipo clásico de la enfermedad. Sin embargo, en la actualidad la mayoría de los pacientes son diagnosticados de forma casual tras realizar una analítica de rutina. Asimismo, se ha descrito una nueva forma de presentación denominada HPP normocalcémico cuya repercusión clínica no se encuentra bien establecida. El perfil bioquímico del HPP se caracteriza por hipercalcemia y concentraciones de PTH elevadas o inapropiadamente normales. La paratiroidectomía es el único tratamiento definitivo para el HPP, aunque algunos pacientes no son candidatos a la cirugía o rechazan la intervención. El tratamiento médico con el calcimimético cinacalcet ha demostrado normalizar la calcemia en un elevado porcentaje de casos.Primary hyperparathyroidism (PHPT) is a common endocrinological process, characterized by chronic elevation of serum concentrations of calcium and parathyroid hormone (PTH). Many years ago, the most frequent forms of clinical presentation were symptomatic renal or skeletal disease with moderate or severe hypercalcemia; however, currently, most patients have few symptoms and mild hypercalcemia. A new form of presentation called normocalcemic PHPT has also been described but clinical consequences are not well established. The biochemical profile of PHPT is characterized by hypercalcemia and high or inappropriately normal PTH concentrations. Parathyroidectomy is the only definitive cure. Medical treatment with the calcimimetic cinacalcet has been shown to normalize calcemia in a high percentage of cases." @default.
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- W1977373357 date "1990-01-01" @default.
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- W1977373357 title "El Láser en Neurocirugía" @default.
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