Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977373441> ?p ?o ?g. }
- W1977373441 endingPage "790" @default.
- W1977373441 startingPage "777" @default.
- W1977373441 abstract "The outcome for malignant glioma patients remains dismal despite treatment with surgical resection, radiation and chemotherapy. The goal of immunotherapy is to eradicate or suppress the residual infiltrative component of these tumors. Although there is clinical evidence for cell-mediated antiglioma activity, there are special considerations that need to be accounted for in the design of immunotherapeutics for CNS tumors, such as possible differences in antigen-presenting cells, trafficking of effector T-cells and immunosuppression. Previously characterized immunosuppression in glioma patients has included low peripheral blood lymphocyte counts, reduced delayed type hypersensitivity reactions to recall antigens, impaired mitogen-induced blastogenic responses by peripheral blood mononuclear cells, increased CD8+ suppressor T-cells, decreased CD4+ T-cell activity in vitro, diminished immunoglobulin synthesis by B-cells and impaired transmembrane signaling through the T-cell receptor/CD3 complex. Recent impairments that are being identified include anergy, failure of costimulation, lack of sufficient numbers of functional effector T-cells and the presence of T-suppressor cells within the tumor microenvironment. It is proposed that these inherent problems will need to be overcome in order for immunotherapies to realize their potential. Paradoxically, the efficacy of recent clinical immunotherapies for glioma patients appears equivalent to that seen in other cancer immunotherapeutic approaches. This review will provide an overview of the juxtaposition of the immune system and CNS, and will discuss the most recent and ongoing immunotherapeutic clinical trials that are demonstrating promising results." @default.
- W1977373441 created "2016-06-24" @default.
- W1977373441 creator A5034433197 @default.
- W1977373441 creator A5079081497 @default.
- W1977373441 date "2005-10-01" @default.
- W1977373441 modified "2023-10-18" @default.
- W1977373441 title "Immunotherapy for human glioma: innovative approaches and recent results" @default.
- W1977373441 cites W1489601317 @default.
- W1977373441 cites W1498680542 @default.
- W1977373441 cites W1559213768 @default.
- W1977373441 cites W1568276869 @default.
- W1977373441 cites W1570056825 @default.
- W1977373441 cites W1579771649 @default.
- W1977373441 cites W1625336221 @default.
- W1977373441 cites W1855377691 @default.
- W1977373441 cites W1959635413 @default.
- W1977373441 cites W1969581694 @default.
- W1977373441 cites W1981688486 @default.
- W1977373441 cites W1983350325 @default.
- W1977373441 cites W1989207092 @default.
- W1977373441 cites W1990800602 @default.
- W1977373441 cites W1992606149 @default.
- W1977373441 cites W1996235568 @default.
- W1977373441 cites W2000909088 @default.
- W1977373441 cites W2002726220 @default.
- W1977373441 cites W2004945180 @default.
- W1977373441 cites W2008688645 @default.
- W1977373441 cites W2010956784 @default.
- W1977373441 cites W2012795872 @default.
- W1977373441 cites W2014071641 @default.
- W1977373441 cites W2017605183 @default.
- W1977373441 cites W2023236831 @default.
- W1977373441 cites W2025366797 @default.
- W1977373441 cites W2026275665 @default.
- W1977373441 cites W2026726491 @default.
- W1977373441 cites W2027159794 @default.
- W1977373441 cites W2035869780 @default.
- W1977373441 cites W2036042351 @default.
- W1977373441 cites W2037383080 @default.
- W1977373441 cites W2041990849 @default.
- W1977373441 cites W2048100508 @default.
- W1977373441 cites W2049914560 @default.
- W1977373441 cites W2051222516 @default.
- W1977373441 cites W2053313675 @default.
- W1977373441 cites W2058006748 @default.
- W1977373441 cites W2060677148 @default.
- W1977373441 cites W2064126767 @default.
- W1977373441 cites W2065552762 @default.
- W1977373441 cites W2070338771 @default.
- W1977373441 cites W2070482685 @default.
- W1977373441 cites W2071808001 @default.
- W1977373441 cites W2074414764 @default.
- W1977373441 cites W2074518737 @default.
- W1977373441 cites W2076281306 @default.
- W1977373441 cites W2076595498 @default.
- W1977373441 cites W2080869340 @default.
- W1977373441 cites W2082102301 @default.
- W1977373441 cites W2083161329 @default.
- W1977373441 cites W2083697291 @default.
- W1977373441 cites W2083873191 @default.
- W1977373441 cites W2085089983 @default.
- W1977373441 cites W2090454492 @default.
- W1977373441 cites W2091882900 @default.
- W1977373441 cites W2092200727 @default.
- W1977373441 cites W2092720139 @default.
- W1977373441 cites W2096287682 @default.
- W1977373441 cites W2098263349 @default.
- W1977373441 cites W2099233769 @default.
- W1977373441 cites W2108114104 @default.
- W1977373441 cites W2110431989 @default.
- W1977373441 cites W2111837231 @default.
- W1977373441 cites W2112320456 @default.
- W1977373441 cites W2121080034 @default.
- W1977373441 cites W2121276929 @default.
- W1977373441 cites W2126763965 @default.
- W1977373441 cites W2135808990 @default.
- W1977373441 cites W2137694635 @default.
- W1977373441 cites W2138864676 @default.
- W1977373441 cites W2141475443 @default.
- W1977373441 cites W2143005230 @default.
- W1977373441 cites W2144616410 @default.
- W1977373441 cites W2145394664 @default.
- W1977373441 cites W2149208882 @default.
- W1977373441 cites W2169838769 @default.
- W1977373441 cites W2169966356 @default.
- W1977373441 cites W2172246347 @default.
- W1977373441 cites W2216821117 @default.
- W1977373441 cites W2337057330 @default.
- W1977373441 cites W2403167038 @default.
- W1977373441 cites W4252910285 @default.
- W1977373441 cites W4256682892 @default.
- W1977373441 cites W775059694 @default.
- W1977373441 doi "https://doi.org/10.1586/14737140.5.5.777" @default.
- W1977373441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16221048" @default.
- W1977373441 hasPublicationYear "2005" @default.
- W1977373441 type Work @default.
- W1977373441 sameAs 1977373441 @default.
- W1977373441 citedByCount "37" @default.