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- W1977401897 abstract "Structural abnormalities in striated muscle have been observed in numerous transcription factor gain- and loss-of-function phenotypes in animal and cell culture model systems, indicating that transcription is important in regulating the cytoarchitecture. While most characterized cytoarchitectural defects are largely indistinguishable by histological and ultrastructural criteria, analysis of dysregulated gene expression in each mutant phenotype has yielded valuable information regarding specific structural gene programs that may be uniquely controlled by each of these transcription factors. Linking the formation and maintenance of each subcellular structure or subset of proteins within a cytoskeletal compartment to an overlapping but distinct transcription factor cohort may enable striated muscle to control cytoarchitectural function in an efficient and specific manner. Here we summarize the available evidence that connects transcription factors, those with established roles in striated muscle such as MEF2 and SRF, as well as other non-muscle transcription factors, to the regulation of a defined cytoskeletal structure. The notion that genes encoding proteins localized to the same subcellular compartment are coordinately transcriptionally regulated may prompt rationally designed approaches that target specific transcription factor pathways to correct structural defects in muscle disease." @default.
- W1977401897 created "2016-06-24" @default.
- W1977401897 creator A5003583561 @default.
- W1977401897 creator A5007112336 @default.
- W1977401897 date "2013-11-12" @default.
- W1977401897 modified "2023-10-10" @default.
- W1977401897 title "Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle" @default.
- W1977401897 cites W1598713761 @default.
- W1977401897 cites W177223209 @default.
- W1977401897 cites W184748523 @default.
- W1977401897 cites W1916270054 @default.
- W1977401897 cites W1964472431 @default.
- W1977401897 cites W1968210959 @default.
- W1977401897 cites W1970944947 @default.
- W1977401897 cites W1971168643 @default.
- W1977401897 cites W1978162225 @default.
- W1977401897 cites W1980692621 @default.
- W1977401897 cites W1982927898 @default.
- W1977401897 cites W1983847126 @default.
- W1977401897 cites W1989731833 @default.
- W1977401897 cites W1992106179 @default.
- W1977401897 cites W1992881039 @default.
- W1977401897 cites W1993105398 @default.
- W1977401897 cites W1994485685 @default.
- W1977401897 cites W1994587676 @default.
- W1977401897 cites W1994735427 @default.
- W1977401897 cites W1995775187 @default.
- W1977401897 cites W1996361830 @default.
- W1977401897 cites W1999513322 @default.
- W1977401897 cites W2001926864 @default.
- W1977401897 cites W2003369513 @default.
- W1977401897 cites W2007452508 @default.
- W1977401897 cites W2008606623 @default.
- W1977401897 cites W2008762833 @default.
- W1977401897 cites W2011182719 @default.
- W1977401897 cites W2011683654 @default.
- W1977401897 cites W2012665197 @default.
- W1977401897 cites W2012743859 @default.
- W1977401897 cites W2017092074 @default.
- W1977401897 cites W2020836040 @default.
- W1977401897 cites W2021044190 @default.
- W1977401897 cites W2021117664 @default.
- W1977401897 cites W2021131295 @default.
- W1977401897 cites W2023255331 @default.
- W1977401897 cites W2026182775 @default.
- W1977401897 cites W2026579495 @default.
- W1977401897 cites W2029918174 @default.
- W1977401897 cites W2030430240 @default.
- W1977401897 cites W2031084374 @default.
- W1977401897 cites W2031713075 @default.
- W1977401897 cites W2031976244 @default.
- W1977401897 cites W2034540200 @default.
- W1977401897 cites W2035975703 @default.
- W1977401897 cites W2038843244 @default.
- W1977401897 cites W2041611268 @default.
- W1977401897 cites W2051287156 @default.
- W1977401897 cites W2053693231 @default.
- W1977401897 cites W2053897822 @default.
- W1977401897 cites W2055694197 @default.
- W1977401897 cites W2057845770 @default.
- W1977401897 cites W2061884629 @default.
- W1977401897 cites W2066695771 @default.
- W1977401897 cites W2072075947 @default.
- W1977401897 cites W2072387160 @default.
- W1977401897 cites W2072540565 @default.
- W1977401897 cites W2073539157 @default.
- W1977401897 cites W2076600697 @default.
- W1977401897 cites W2078422108 @default.
- W1977401897 cites W2078718449 @default.
- W1977401897 cites W2080975812 @default.
- W1977401897 cites W2083055314 @default.
- W1977401897 cites W2083779268 @default.
- W1977401897 cites W2083853503 @default.
- W1977401897 cites W2084272633 @default.
- W1977401897 cites W2087377825 @default.
- W1977401897 cites W2087772215 @default.
- W1977401897 cites W2090392605 @default.
- W1977401897 cites W2093588238 @default.
- W1977401897 cites W2094863064 @default.
- W1977401897 cites W2096725497 @default.
- W1977401897 cites W2096751146 @default.
- W1977401897 cites W2098209017 @default.
- W1977401897 cites W2098972920 @default.
- W1977401897 cites W2099304566 @default.
- W1977401897 cites W2100896408 @default.
- W1977401897 cites W2100917533 @default.
- W1977401897 cites W2102312968 @default.
- W1977401897 cites W2103274097 @default.
- W1977401897 cites W2106644177 @default.
- W1977401897 cites W2106682123 @default.
- W1977401897 cites W2107575131 @default.
- W1977401897 cites W2107840287 @default.
- W1977401897 cites W2111525541 @default.
- W1977401897 cites W2111991662 @default.
- W1977401897 cites W2112465301 @default.
- W1977401897 cites W2113431091 @default.
- W1977401897 cites W2114347193 @default.
- W1977401897 cites W2116484480 @default.