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- W1977426511 abstract "Abstract Sympathomimetic agents inhibit antigen-induced release of histamine in animal experiments and in in vitro studies of human tissue, but the significance of this effect for treatment of allergic airway diseases has not been established. It was the aim of our study to investigate the protective effect of the beta-2 adrenostimulant fenoterol on allergen-induced nasal symptoms and to relate the efficacy to dose and time. In a double-blind crossover design 16 patients with hay fever were challenged with grass pollen extract in the nose after pretreatment with intranasal placebo and fenoterol in different doses, delivered as a micronized powder from a pressurized canister and as a watery solution from a pump spray. Sneezing was recorded, and rhinorrhea and changes in nasal airway resistance were measured for 15 min after the provocation. Fenoterol, micronized powder as well as solution, had a marked inhibitory effect on all three nasal symptoms (p" @default.
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- W1977426511 date "1980-07-01" @default.
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- W1977426511 title "Inhibition of the immediate allergic reaction in the nose by the beta-2 adrenostimulant fenoterol" @default.
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- W1977426511 doi "https://doi.org/10.1016/0091-6749(80)90134-7" @default.
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